Trait

Decreased facial expression

A reduced degree of voluntary and involuntary facial movements involved in responded to others or expressing emotions.

Body system: Abnormality of head or neck

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/decreased-facial-expression.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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12 genes linked to Decreased facial expression

Changes in these genes cause rare conditions in which Decreased facial expression is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
PIEZO2piezo type mechanosensitive ion channel component 2	Always	In 1 condition
PIGAphosphatidylinositol glycan anchor biosynthesis class A	Always	In 1 condition
DNA2DNA replication helicase/nuclease 2	Often (30–79%)	In 2 conditions
DNMT3BDNA methyltransferase 3 beta	Often (30–79%)	In 1 condition
DUX4double homeobox 4	Often (30–79%)	In 1 condition
DUX4L1double homeobox 4 like 1 (pseudogene)	Often (30–79%)	In 1 condition
FRG1FSHD region gene 1	Often (30–79%)	In 1 condition
SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1	Often (30–79%)	In 1 condition
ASXL3ASXL transcriptional regulator 3	Sometimes (5–29%)	In 1 condition
DLK1delta like non-canonical Notch ligand 1	Sometimes (5–29%)	In 1 condition
MEG3maternally expressed 3	Sometimes (5–29%)	In 1 condition
RTL1retrotransposon Gag like 1	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal facial expression

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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