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Gene

FAT1

FAT atypical cadherin 1

Summary

Cytogenetic location
4q35.2
Coordinates
Chromosome 4: 186,587,794–186,723,856 (GRCh38)
Exons
27 exons across 136.1 kb
Protein
4,588 amino acids
Also known as
CDHF7, CDHR8
Previous symbols
FAT
MANE Select transcript
ENST00000441802.7NM_005245.4
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Focal Segmental Glomerulosclerosis

    • A renal disorder characterized by sclerotic lesions in the glomeruli. Causes include drugs, viruses, and malignancies (lymphomas), or it may be idiopathic. It presents with asymptomatic proteinuria or nephritic syndrome and it may lead to renal failure.

      • ClinGen rates the link strong
      • 1 GenCC submitter rates it definitive or strong

  • Glomerulosclerosis

    • A hardening of the kidney glomerulus caused by scarring of the blood vessels.

      • ClinGen rates the link strong
      • 1 GenCC submitter rates it definitive or strong

  • Microphthalmia, Anophthalmia & Coloboma

    • Syndromic Microphthalmia

      Microphthalmia occurring with features outside the eye, caused by changes in genes such as SOX2, OTX2, BCOR, STRA6 and BMP4.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      A genetic diagnosis guides checks for associated features, such as pituitary hormone problems with SOX2 or OTX2, and informs recurrence risk.

How FAT1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 4, with a bracket where FAT1 sits. FAT1 and 7 genes near it on chromosome 4, from 186,155,825 to 187,155,824.Chromosome 44q35.2p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.2186.2 Mb186.4 Mb186.6 Mb186.8 Mb187 MbFAM149A: 186,104,419–186,175,437, forward strandFAM149ACYP4V2: 186,191,258–186,215,245, forward strandCYP4V2: 186,208,979–186,258,469, forward strandKLKB1: 186,225,424–186,258,476, forward strandKLKB1F11: 186,260,159–186,291,745, forward strandF11: 186,426,546–186,555,328, reverse strandMTNR1A: 186,526,792–186,555,567, reverse strandMTNR1AFAT1: 186,587,794–186,723,856, reverse strandFAT1Diagram of FAT1: 27 exons on the reverse strand of chromosome 4Exon 27: 186,587,794–186,589,220, 1,427 basesExon 26: 186,595,689–186,595,826, 138 basesExon 25: 186,596,540–186,597,171, 632 basesExon 24: 186,597,682–186,597,792, 111 basesExon 23: 186,597,972–186,598,125, 154 basesExon 22: 186,599,898–186,600,360, 463 basesExon 21: 186,601,269–186,601,426, 158 basesExon 20: 186,602,903–186,603,034, 132 basesExon 19: 186,603,176–186,603,977, 802 basesExon 18: 186,604,377–186,604,574, 198 basesExon 17: 186,606,070–186,606,213, 144 basesExon 16: 186,609,183–186,609,320, 138 basesExon 15: 186,609,801–186,610,015, 215 basesExon 14: 186,611,386–186,611,775, 390 basesExon 13: 186,613,109–186,613,342, 234 basesExon 12: 186,614,191–186,614,344, 154 basesExon 11: 186,617,005–186,617,201, 197 basesExon 10: 186,617,708–186,621,775, 4,068 basesExon 9: 186,628,154–186,628,364, 211 basesExon 8: 186,628,488–186,628,763, 276 basesExon 7: 186,633,684–186,633,823, 140 basesExon 6: 186,636,025–186,636,235, 211 basesExon 5: 186,636,585–186,636,914, 330 basesExon 4: 186,639,722–186,639,783, 62 basesExon 3: 186,663,299–186,663,613, 315 basesExon 2: 186,706,563–186,709,845, 3,283 basesExon 1: 186,723,664–186,723,856, 193 bases2725201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 14.8 kb of the gene's 136.1 kb; 13,767 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FAT1 gene: FAT atypical cadherin 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/fat1

Vancouver

Dante Labs. FAT1 gene: FAT atypical cadherin 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/fat1

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