Trait

Peters anomaly

A form of anterior segment dysgenesis in which abnormal cleavage of the anterior chamber occurs. Peters anomaly is characterized by central, paracentral, or complete corneal opacity.

HPO HP:0000659

Body system: Abnormality of the eye

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29 genes linked to Peters anomaly

Changes in these genes cause rare conditions in which Peters anomaly is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
CYP1B1cytochrome P450 family 1 subfamily B member 1	Always	In 1 condition
EXOC3L2exocyst complex component 3 like 2	Always	In 1 condition
FOXC1forkhead box C1	Always	In 3 conditions
FOXE3forkhead box E3	Always	In 2 conditions
PAX6paired box 6	Always	In 4 conditions
PITX2paired like homeodomain 2	Always	In 1 condition
B3GLCTbeta 3-glucosyltransferase	Very often (80–99%)	In 2 conditions
KDM6Alysine demethylase 6A	Often (30–79%)	In 1 condition
KMT2Dlysine methyltransferase 2D	Often (30–79%)	In 1 condition
NCAPG2non-SMC condensin II complex subunit G2	Often (30–79%)	In 1 condition
POMT2protein O-mannosyltransferase 2	Often (30–79%)	In 2 conditions
PRR12proline rich 12	Often (30–79%)	In 1 condition
TRIM44TRIM family member 44	Often (30–79%)	In 1 condition
CACHD1cache domain containing 1	Sometimes (5–29%)	In 1 condition
CDH2cadherin 2	Sometimes (5–29%)	In 1 condition
COX7Bcytochrome c oxidase subunit 7B	Sometimes (5–29%)	In 1 condition
CRPPACDP-L-ribitol pyrophosphorylase A	Sometimes (5–29%)	In 1 condition
DNA2DNA replication helicase/nuclease 2	Sometimes (5–29%)	In 1 condition
HCCSholocytochrome c synthase	Sometimes (5–29%)	In 1 condition
MAFMAF bZIP transcription factor	Sometimes (5–29%)	In 1 condition
NDUFB11NADH:ubiquinone oxidoreductase subunit B11	Sometimes (5–29%)	In 1 condition
REREarginine-glutamic acid dipeptide repeats	Sometimes (5–29%)	In 2 conditions
WDR37WD repeat domain 37	Sometimes (5–29%)	In 1 condition
CENPFcentromere protein F	Not recorded	In 1 condition
FKRPfukutin related protein	Not recorded	In 1 condition
FKTNfukutin	Not recorded	In 1 condition
LARGE1LARGE xylosyl- and glucuronyltransferase 1	Not recorded	In 1 condition
PITX3paired like homeodomain 3	Not recorded	In 1 condition
POMT1protein O-mannosyltransferase 1	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Ocular anterior segment dysgenesis

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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