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Gene

NTRK2

neurotrophic receptor tyrosine kinase 2

Summary

Cytogenetic location
9q21.33
Coordinates
Chromosome 9: 84,669,729–85,027,054 (GRCh38)
Exons
19 exons across 357.3 kb
Protein
838 amino acids
Also known as
TRKB
MANE Select transcript
ENST00000277120.8NM_006180.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 3 GenCC submitters rate it definitive or strong

    How NTRK2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 9, with a bracket where NTRK2 sits. NTRK2 and 1 gene near it on chromosome 9, from 84,312,403 to 85,384,380.Chromosome 99q21.33p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.384.4 Mb84.6 Mb84.8 Mb85 Mb85.2 MbSLC28A3: 84,275,457–84,340,758, reverse strandSLC28A3NTRK2: 84,669,729–85,027,054, forward strandNTRK2Diagram of NTRK2: 19 exons on the forward strand of chromosome 9Exon 11: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 1: 84,669,729–84,669,888, 160 basesExon 2: 84,670,377–84,670,960, 584 basesExon 3: 84,702,159–84,702,233, 75 basesExon 4: 84,702,348–84,702,419, 72 basesExon 5: 84,707,844–84,707,912, 69 basesExon 6: 84,710,637–84,710,791, 155 basesExon 7: 84,723,573–84,723,709, 137 basesExon 8: 84,724,224–84,724,356, 133 basesExon 9: 84,727,654–84,727,959, 306 basesExon 10: 84,741,892–84,741,927, 36 basesExon 11: 84,744,973–84,745,073, 101 basesExon 12: 84,751,986–84,752,085, 100 basesExon 13: 84,861,040–84,861,087, 48 basesExon 14: 84,867,243–84,867,431, 189 basesExon 15: 84,934,162–84,934,292, 131 basesExon 16: 84,948,462–84,948,634, 173 basesExon 17: 84,955,283–84,955,517, 235 basesExon 18: 85,020,206–85,020,364, 159 basesExon 19: 85,021,252–85,027,054, 5,803 bases151015195′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 8.7 kb of the gene's 357.3 kb; 2,517 of those bases code for the protein.

    How a genome test reads NTRK2

    5

    positions in NTRK2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 357.3 kb of NTRK2, introns included, not only the 8.7 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). NTRK2 gene: neurotrophic receptor tyrosine kinase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/ntrk2

    Vancouver

    Dante Labs. NTRK2 gene: neurotrophic receptor tyrosine kinase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ntrk2

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