Traits

Traits linked to IL2RG

interleukin 2 receptor subunit gamma

The Human Phenotype Ontology links 72 traits to IL2RG, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the immune system

Trait	Kaip dažnai pasireiškia
Combined immunodeficiency	Visada
Pneumocystis jirovecii pneumonia	Visada
Pneumonia	Labai dažnai (80–99%)
Red scaly skin caused by inflammatory skin disease	Labai dažnai (80–99%)
Severe combined immunodeficiency	Labai dažnai (80–99%)
Infection in blood stream	Dažnai (30–79%)
Recurrent bacterial infections	Dažnai (30–79%)
Recurrent opportunistic infections	Dažnai (30–79%)
Recurrent pneumonia	Dažnai (30–79%)
Skin rash	Dažnai (30–79%)
Autoimmunity	Kartais (5–29%)
Recurrent bacterial skin infections	Kartais (5–29%)
Recurrent cutaneous fungal infections	Kartais (5–29%)
Recurrent Haemophilus influenzae infection	Kartais (5–29%)
Recurrent mucocutaneous candidiasis	Kartais (5–29%)
Severe recurrent varicella	Kartais (5–29%)
Susceptibility to herpesvirus	Kartais (5–29%)
Recurrent bacterial meningitis	Neužfiksuota
Recurrent bronchitis	Neužfiksuota
Recurrent fungal infections	Neužfiksuota
Severe T-cell immunodeficiency	Neužfiksuota

Abnormality of blood and blood-forming tissues

Trait	Kaip dažnai pasireiškia
Abnormal lymphocyte morphology	Labai dažnai (80–99%)
Decreased blood lymphocyte number	Labai dažnai (80–99%)
Decreased naive T cell proportion	Labai dažnai (80–99%)
Decreased total CD4+ T cell proportion	Labai dažnai (80–99%)
Reduced total natural killer cell count	Labai dažnai (80–99%)
Abnormally low T cell receptor excision circle level	Dažnai (30–79%)
Elevated white blood count	Dažnai (30–79%)
High blood eosinophil count	Dažnai (30–79%)
Low T cell count	Dažnai (30–79%)
Cancer of lymphatic system	Kartais (5–29%)
Low number of red blood cells or hemoglobin	Kartais (5–29%)
Lymphoproliferative disorder	Retai (1–4 %)
Decreased total CD8+ T cell proportion	Neužfiksuota

Abnormal cellular phenotype

Trait	Kaip dažnai pasireiškia
Abnormal circulating immunoglobulin concentration	Labai dažnai (80–99%)
Decreased mitogen-induced T-cell proliferation	Labai dažnai (80–99%)
Decreased circulating IgA concentration	Dažnai (30–79%)
Decreased circulating IgG concentration	Dažnai (30–79%)
Increased circulating IgG concentration	Retai (1–4 %)
Abnormal natural killer cell physiology	Neužfiksuota
Agammaglobulinemia	Neužfiksuota
Decreased circulating IgE concentration	Neužfiksuota
Decreased circulating IgM concentration	Neužfiksuota
Impaired phytohemagglutinin-induced T lymphocyte transformation	Neužfiksuota

Abnormality of the cardiovascular system

Trait	Kaip dažnai pasireiškia
Swollen lymph nodes	Labai dažnai (80–99%)
Increased spleen size	Dažnai (30–79%)
Absent tonsils	Kartais (5–29%)
Small lymph nodes	Kartais (5–29%)
Small thymus	Neužfiksuota

Abnormality of the digestive system

Trait	Kaip dažnai pasireiškia
Chronic diarrhea	Labai dažnai (80–99%)
Enlarged liver	Labai dažnai (80–99%)
Diarrhea	Dažnai (30–79%)
Jaundice	Retai (1–4 %)

Abnormality of the integument

Trait	Kaip dažnai pasireiškia
Hair loss	Labai dažnai (80–99%)
Dry skin	Dažnai (30–79%)
Itching	Dažnai (30–79%)
Thickened skin	Dažnai (30–79%)

Abnormality of head or neck

Trait	Kaip dažnai pasireiškia
Chronic oral thrush	Dažnai (30–79%)
Sparse or absent eyebrows	Dažnai (30–79%)
Sinus disease	Neužfiksuota

Laboratory abnormality

Trait	Kaip dažnai pasireiškia
Episodic fever	Labai dažnai (80–99%)
Fever	Dažnai (30–79%)
Fluid retention	Dažnai (30–79%)

Abnormality of limbs

Trait	Kaip dažnai pasireiškia
Abnormality of the wide portion of a long bone	Kartais (5–29%)
Short toe	Kartais (5–29%)

Abnormality of the endocrine system

Trait	Kaip dažnai pasireiškia
Thyroid gland inflammation	Kartais (5–29%)
Underactive thyroid	Kartais (5–29%)

Abnormality of prenatal development or birth

Trait	Kaip dažnai pasireiškia
Desquamation of skin soon after birth	Dažnai (30–79%)

Abnormality of the ear

Trait	Kaip dažnai pasireiškia
Middle ear infection	Neužfiksuota

Abnormality of the genitourinary system

Trait	Kaip dažnai pasireiškia
Nephrotic syndrome	Kartais (5–29%)

Abnormality of the respiratory system

Trait	Kaip dažnai pasireiškia
Cough	Dažnai (30–79%)

Growth abnormality

Trait	Kaip dažnai pasireiškia
Faltering weight	Labai dažnai (80–99%)

Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.

Iš kur tai žinoma

The Human Phenotype Ontology, release 2026-09-01: the traits linked to IL2RG and how often each is seen. Find out more at hpo.jax.org.

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