Skip to content
Use your HSA or FSA funds

Gene

CSF2RB

colony stimulating factor 2 receptor subunit beta

Summary

Cytogenetic location
22q12.3
Coordinates
Chromosome 22: 36,913,628–36,940,439 (GRCh38)
Exons
14 exons across 26.8 kb
Protein
897 amino acids
Also known as
IL5RB, CD131, betaGMR
Previous symbols
IL3RB
MANE Select transcript
ENST00000403662.8NM_000395.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Surfactant Metabolism Dysfunction

    • Hereditary Pulmonary Alveolar Proteinosis and Surfactant Dysfunction

      Inherited disorders of surfactant production or clearance, including those caused by SFTPB, SFTPC, ABCA3, CSF2RA, CSF2RB and MARS1, that range from fatal respiratory distress in newborns to interstitial lung disease in children and adults.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing can support earlier diagnosis, specialist respiratory care, consideration of whole-lung lavage or transplant where appropriate, and information for family planning.

How CSF2RB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 22, with a bracket where CSF2RB sits. CSF2RB and 18 genes near it on chromosome 22, from 36,427,034 to 37,427,033.Chromosome 2222q12.3p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3336.6 Mb36.8 Mb37 Mb37.2 Mb37.4 MbTXN2: 36,466,895–36,482,072, reverse strandTXN2FOXRED2: 36,487,190–36,507,221, reverse strandFOXRED2EIF3D: 36,510,847–36,529,245, reverse strandEIF3DCACNG2: 36,560,857–36,703,779, reverse strandCACNG2IFT27: 36,741,346–36,776,309, reverse strandIFT27PVALB: 36,800,682–36,819,479, reverse strandPVALBNCF4: 36,860,795–36,878,067, forward strandNCF4CSF2RB: 36,913,628–36,940,439, forward strandCSF2RBCIMIP4: 36,991,119–37,007,884, reverse strandCIMIP4TST: 37,010,859–37,024,797, reverse strandTSTMPST: 37,019,635–37,029,828, forward strandMPSTKCTD17: 37,051,705–37,063,390, forward strandKCTD17TMPRSS6: 37,065,005–37,110,890, reverse strandTMPRSS6IL2RB: 37,118,666–37,176,676, reverse strandIL2RBC1QTNF6: 37,180,166–37,199,385, reverse strandC1QTNF6SSTR3: 37,204,237–37,212,482, reverse strandSSTR3RAC2: 37,225,270–37,259,594, reverse strandRAC2CYTH4: 37,282,027–37,315,346, forward strandCYTH4ELFN2: 37,367,960–37,427,596, reverse strandELFN2Diagram of CSF2RB: 14 exons on the forward strand of chromosome 22Exon 1: 36,913,628–36,913,677, 50 basesExon 2: 36,922,036–36,922,283, 248 basesExon 3: 36,923,244–36,923,367, 124 basesExon 4: 36,925,987–36,926,177, 191 basesExon 5: 36,929,402–36,929,559, 158 basesExon 6: 36,929,639–36,929,807, 169 basesExon 7: 36,930,375–36,930,510, 136 basesExon 8: 36,930,673–36,930,830, 158 basesExon 9: 36,932,765–36,932,904, 140 basesExon 10: 36,933,832–36,933,994, 163 basesExon 11: 36,935,351–36,935,441, 91 basesExon 12: 36,935,630–36,935,687, 58 basesExon 13: 36,936,549–36,936,652, 104 basesExon 14: 36,937,377–36,940,439, 3,063 bases124681012145′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 26.8 kb; 2,694 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CSF2RB gene: colony stimulating factor 2 receptor subunit beta. Retrieved 16 October 2026, from https://dantelabs.com/genes/csf2rb

Vancouver

Dante Labs. CSF2RB gene: colony stimulating factor 2 receptor subunit beta [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/csf2rb

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test