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Gene

RNF43

ring finger protein 43

Summary

Cytogenetic location
17q22
Coordinates
Chromosome 17: 58,353,676–58,417,534 (GRCh38)
Exons
10 exons across 63.9 kb
Protein
783 amino acids
Also known as
FLJ20315, RNF124, DKFZp781H0392, URCC
MANE Select transcript
ENST00000407977.7NM_017763.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads RNF43 yet. The test sequences your whole genome, so your data includes it all the same.

How RNF43 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where RNF43 sits. RNF43 and 21 genes near it on chromosome 17, from 57,885,605 to 58,885,604.Chromosome 1717q22p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.358 Mb58.2 Mb58.4 Mb58.6 Mb58.8 MbCUEDC1: 57,861,231–57,955,851, reverse strandCUEDC1VEZF1: 57,971,547–57,988,389, reverse strandVEZF1: 57,989,038–58,007,246, reverse strandSRSF1: 57,996,889–58,007,346, reverse strandSRSF1DYNLL2: 58,082,825–58,095,542, forward strandDYNLL2OR4D1: 58,148,384–58,159,585, forward strandOR4D1OR4D2: 58,166,982–58,171,411, forward strandOR4D2EPX: 58,192,726–58,205,174, forward strandEPXMKS1: 58,205,350–58,219,605, reverse strandMKS1LPO: 58,218,548–58,268,518, forward strandLPOMPO: 58,269,855–58,280,935, reverse strandMPOTSPOAP1: 58,301,228–58,328,823, reverse strandTSPOAP1SUPT4H1: 58,345,175–58,353,099, reverse strandSUPT4H1: 58,345,206–58,417,595, reverse strandRNF43: 58,353,676–58,417,534, reverse strandRNF43HSF5: 58,420,167–58,488,408, reverse strandHSF5MTMR4: 58,489,529–58,517,905, reverse strandMTMR4SEPTIN4: 58,519,969–58,544,368, reverse strandSEPTIN4TEX14: 58,556,678–58,692,055, reverse strandTEX14IGBP1C: 58,660,424–58,692,055, reverse strandIGBP1CRAD51C: 58,692,569–58,735,611, forward strandRAD51CPPM1E: 58,755,851–58,985,179, forward strandPPM1EDiagram of RNF43: 10 exons on the reverse strand of chromosome 17Exon 9: 31 known disease-causing sitesExon 8: 1 known disease-causing siteExon 7: 4 known disease-causing sitesExon 6: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 2: 2 known disease-causing sitesExon 10: 58,353,676–58,354,986, 1,311 basesExon 9: 58,357,468–58,358,823, 1,356 basesExon 8: 58,360,149–58,360,251, 103 basesExon 7: 58,360,783–58,360,944, 162 basesExon 6: 58,362,544–58,362,648, 105 basesExon 5: 58,363,275–58,363,406, 132 basesExon 4: 58,363,526–58,363,600, 75 basesExon 3: 58,370,911–58,371,033, 123 basesExon 2: 58,415,326–58,415,962, 637 basesExon 1: 58,417,017–58,417,534, 518 bases10515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.5 kb of the gene's 63.9 kb; 2,352 of those bases code for the protein.

How a genome test reads RNF43

49

positions in RNF43 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 63.9 kb of RNF43, introns included, not only the 4.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RNF43 gene: ring finger protein 43. Retrieved 17 October 2026, from https://dantelabs.com/genes/rnf43

Vancouver

Dante Labs. RNF43 gene: ring finger protein 43 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rnf43

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