Traits

Traits linked to PTCRA

pre T cell antigen receptor alpha

The Human Phenotype Ontology links 71 traits to PTCRA, by body system: features seen in people with one of the gene's rare conditions.

PTCRA

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Abnormally low T cell receptor excision circle level	Always
Cancer of lymphatic system	Always
Decreased blood leukocyte number	Always
Decreased class-switched memory B cell proportion	Always
Decreased naive CD4+ T cell proportion	Always
Decreased total CD4+ T cell proportion	Always
Erythroid dysplasia	Always
High lymphocyte count	Always
Low B cell count	Always
Low blood cell count	Always
Low blood neutrophil count	Always
Low number of red blood cells or hemoglobin	Always
Low platelet count	Always
Low T cell count	Always
Decreased blood lymphocyte number	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
Allergy	Always
Chronic tinea infection	Always
Decreased immune function	Always
Eczema	Always
Partial absence of specific antibody response to unconjugated pneumococcus polysaccharide	Always
Recurrent chest infections	Always
Recurrent infections	Always
Recurrent pneumonia	Always
Recurrent respiratory infections	Always
Recurrent sinus and lung infections	Always
Skin rash	Always
Susceptibility to herpesvirus	Always
Anti-thyroglobulin antibody positivity	Often (30–79%)
Anti-thyroid peroxidase antibody positivity	Often (30–79%)
Partial absence of specific antibody response to tetanus vaccine	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Enlarged liver and spleen	Always
Follicular hyperplasia	Always
Increased spleen size	Always
Inflammation of the lymph nodes	Always
Portal hypertension	Always
Swollen lymph nodes in center of chest	Always

Abnormality of the digestive system

Trait	How often it is seen
Accumulation of fluid in the abdomen	Always
Anorexia	Always
Chronic diarrhea	Always
Duodenitis	Always
Jaundice	Always
Villous atrophy	Always

Abnormality of the nervous system

Trait	How often it is seen
Autism spectrum disorder	Always
Impaired heel-walking ability	Always
Impaired toe-walking ability	Always
Perianal anesthesia	Always
Peripheral nerve disease	Always

Abnormality of the respiratory system

Trait	How often it is seen
Crackles	Always
Increased respiratory rate or depth of breathing	Always
Permanent enlargement of the airways of the lungs	Always
Respiratory failure	Always
Wet cough	Always

Abnormality of head or neck

Trait	How often it is seen
Dry eye syndrome	Always
Pink eye	Always
Recurrent colds	Always
Sinus disease	Always

Laboratory abnormality

Trait	How often it is seen
Fever	Always
High liver enzymes	Always
Low albumin	Always

Abnormality of limbs

Trait	How often it is seen
Clubbing of fingers	Always
Hyporeflexia of lower limbs	Always

Abnormality of the endocrine system

Trait	How often it is seen
Overactive thyroid	Always
Underactive thyroid	Always

Abnormality of the musculoskeletal system

Trait	How often it is seen
Lumbago	Always
Muscle weakness	Always

Constitutional symptom

Trait	How often it is seen
Fatigue	Always
Lack of energy and strength	Always

Abnormal cellular phenotype

Trait	How often it is seen
Panhypogammaglobulinemia	Always

Abnormality of the genitourinary system

Trait	How often it is seen
Urinary retention	Always

Abnormality of the integument

Trait	How often it is seen
Alopecia universalis	Always

Growth abnormality

Trait	How often it is seen
Weight loss	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PTCRA and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test