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Trait

Alopecia universalis

Loss of all hair on the entire body.

HPO HP:0002289

Summary

Also called
Alopecia, complete
Body system
Abnormality of the integument

15 genes linked to Alopecia universalis

Changes in these genes cause rare conditions in which Alopecia universalis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
DSPdesmoplakinAlwaysIn 1 condition
HRHR lysine demethylase and nuclear receptor corepressorAlwaysIn 2 conditions
IL2RAinterleukin 2 receptor subunit alphaAlwaysIn 1 condition
KRT81keratin 81AlwaysIn 1 condition
NHEJ1non-homologous end joining factor 1AlwaysIn 1 condition
PERPp53 apoptosis effector related to PMP22AlwaysIn 1 condition
PTCRApre T cell antigen receptor alphaAlwaysIn 1 condition
RNU6ATACRNA, U6atac small nuclearAlwaysIn 1 condition
VDRvitamin D receptorAlwaysIn 1 condition
LMNAlamin A/CVery often (80–99%)In 1 condition
AHSGalpha 2-HS glycoproteinOften (30–79%)In 1 condition
PKP1plakophilin 1Often (30–79%)In 1 condition
AIREautoimmune regulatorSometimes (5–29%)In 1 condition
SNRPEsmall nuclear ribonucleoprotein polypeptide ESometimes (5–29%)In 1 condition
TRPV3transient receptor potential cation channel subfamily V member 3Sometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Hair loss

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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