Trait

Susceptibility to herpesvirus

Clinical name: Recurrent herpes

Increased susceptibility to herpesvirus, as manifested by recurrent episodes of herpesvirus.

HPO HP:0005353

Body system: Abnormality of the immune system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/recurrent-herpes.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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21 genes linked to Susceptibility to herpesvirus

Changes in these genes cause rare conditions in which Susceptibility to herpesvirus is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ARHGEF1Rho guanine nucleotide exchange factor 1	Always	In 1 condition
CASP8caspase 8	Always	In 1 condition
CD247CD247 molecule	Always	In 2 conditions
DPP9dipeptidyl peptidase 9	Always	In 1 condition
IRF4interferon regulatory factor 4	Always	In 1 condition
PTCRApre T cell antigen receptor alpha	Always	In 1 condition
CIITAclass II major histocompatibility complex transactivator	Often (30–79%)	In 1 condition
RFX5regulatory factor X5	Often (30–79%)	In 1 condition
RFXANKregulatory factor X associated ankyrin containing protein	Often (30–79%)	In 1 condition
RFXAPregulatory factor X associated protein	Often (30–79%)	In 1 condition
STAT1signal transducer and activator of transcription 1	Often (30–79%)	In 1 condition
BLMBLM RecQ like helicase	Sometimes (5–29%)	In 1 condition
CD3DCD3 delta subunit of T-cell receptor complex	Sometimes (5–29%)	In 1 condition
CD3ECD3 epsilon subunit of T-cell receptor complex	Sometimes (5–29%)	In 1 condition
IL2RGinterleukin 2 receptor subunit gamma	Sometimes (5–29%)	In 1 condition
STAT5Bsignal transducer and activator of transcription 5B	Sometimes (5–29%)	In 1 condition
WASWASP actin nucleation promoting factor	Sometimes (5–29%)	In 1 condition
IGHG2immunoglobulin heavy constant gamma 2 (G2m marker)	Rarely (1–4%)	In 1 condition
IGKCimmunoglobulin kappa constant	Rarely (1–4%)	In 1 condition
MBL2mannose binding lectin 2	Not recorded	In 1 condition
UNC93B1unc-93B1 regulator of TLR signaling	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Unusual virus reactivation

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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