Trait
Unexplained fevers
Episodes of fever for which no infectious cause can be identified.
Summary
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test21 genes linked to Unexplained fevers
Changes in these genes cause rare conditions in which Unexplained fevers is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| GALCgalactosylceramidase | Very often (80–99%) | In 1 condition |
| PSAPprosaposin | Very often (80–99%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Often (30–79%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Often (30–79%) | In 1 condition |
| LSM11LSM11, U7 small nuclear RNA associated | Often (30–79%) | In 1 condition |
| RNASEH2Aribonuclease H2 subunit A | Often (30–79%) | In 1 condition |
| RNASEH2Bribonuclease H2 subunit B | Often (30–79%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Often (30–79%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Often (30–79%) | In 1 condition |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Often (30–79%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Often (30–79%) | In 1 condition |
| CRLS1cardiolipin synthase 1 | Sometimes (5–29%) | In 1 condition |
| LAMA3laminin subunit alpha 3 | Sometimes (5–29%) | In 1 condition |
| LAMB3laminin subunit beta 3 | Sometimes (5–29%) | In 1 condition |
| LAMC2laminin subunit gamma 2 | Sometimes (5–29%) | In 1 condition |
| NTRK1neurotrophic receptor tyrosine kinase 1 | Sometimes (5–29%) | In 1 condition |
| TMEM165transmembrane protein 165 | Sometimes (5–29%) | In 1 condition |
| NKX2-1NK2 homeobox 1 | Rarely (1–4%) | In 1 condition |
| AQP2aquaporin 2 | Not recorded | In 1 condition |
| AVPR2arginine vasopressin receptor 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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