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Trait

Coronal cleft vertebrae

Frontal schisis (cleft or cleavage) of vertebral bodies.

HPO HP:0003417

Summary

Also called
coronal cleft of vertebrae, Coronal clefts, Coronal vertebral clefts, Vertebral coronal clefts
Body system
Abnormality of the musculoskeletal system

18 genes linked to Coronal cleft vertebrae

Changes in these genes cause rare conditions in which Coronal cleft vertebrae is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
COL2A1collagen type II alpha 1 chainAlwaysIn 2 conditions
CSGALNACT1chondroitin sulfate N-acetylgalactosaminyltransferase 1AlwaysIn 1 condition
FLNBfilamin BAlwaysIn 3 conditions
GNPATglyceronephosphate O-acyltransferaseAlwaysIn 1 condition
HSPA9heat shock protein family A (Hsp70) member 9AlwaysIn 1 condition
IARS2isoleucyl-tRNA synthetase 2, mitochondrialAlwaysIn 1 condition
LONP1lon peptidase 1, mitochondrialVery often (80–99%)In 2 conditions
ALDH1A2aldehyde dehydrogenase 1 family member A2Often (30–79%)In 1 condition
HSPG2heparan sulfate proteoglycan 2Often (30–79%)In 1 condition
LAMA5laminin subunit alpha 5Often (30–79%)In 1 condition
ARSLarylsulfatase LSometimes (5–29%)In 1 condition
COL11A2collagen type XI alpha 2 chainSometimes (5–29%)In 2 conditions
SLC10A7solute carrier family 10 member 7Sometimes (5–29%)In 1 condition
TRPV4transient receptor potential cation channel subfamily V member 4Sometimes (5–29%)In 1 condition
CHST3carbohydrate sulfotransferase 3Not recordedIn 1 condition
PEX7peroxisomal biogenesis factor 7Not recordedIn 1 condition
SLC26A2solute carrier family 26 member 2Not recordedIn 1 condition
TRIP11thyroid hormone receptor interactor 11Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Vertebral clefting

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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