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Gene

ARMC2

armadillo repeat containing 2

Summary

Cytogenetic location
6q21
Coordinates
Chromosome 6: 108,848,422–108,974,476 (GRCh38)
Exons
18 exons across 126.1 kb
Protein
867 amino acids
Also known as
DKFZp434P0714, bA787I22.1
MANE Select transcript
ENST00000392644.9NM_032131.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Male Infertility

    • The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong

How ARMC2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where ARMC2 sits. ARMC2 and 6 genes near it on chromosome 6, from 108,411,449 to 109,411,448.Chromosome 66q21p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27108.6 Mb108.8 Mb109 Mb109.2 Mb109.4 MbAFG1L: 108,294,892–108,526,796, forward strandAFG1LFOXO3: 108,559,652–108,684,774, forward strandFOXO3ARMC2: 108,848,422–108,974,476, forward strandARMC2SESN1: 108,984,309–109,095,097, reverse strandSESN1CEP57L1: 109,095,105–109,174,418, forward strandCEP57L1CD164: 109,307,627–109,382,536, reverse strandCD164PPIL6: 109,390,215–109,441,171, reverse strandPPIL6Diagram of ARMC2: 18 exons on the forward strand of chromosome 6Exon 13: 1 known disease-causing siteExon 1: 108,848,422–108,848,546, 125 basesExon 2: 108,854,225–108,854,485, 261 basesExon 3: 108,858,199–108,858,271, 73 basesExon 4: 108,868,824–108,868,995, 172 basesExon 5: 108,876,143–108,876,350, 208 basesExon 6: 108,894,467–108,894,543, 77 basesExon 7: 108,899,694–108,899,792, 99 basesExon 8: 108,904,230–108,904,405, 176 basesExon 9: 108,910,899–108,911,001, 103 basesExon 10: 108,912,335–108,912,558, 224 basesExon 11: 108,928,088–108,928,233, 146 basesExon 12: 108,936,900–108,936,999, 100 basesExon 13: 108,953,033–108,953,351, 319 basesExon 14: 108,961,572–108,961,694, 123 basesExon 15: 108,962,014–108,962,127, 114 basesExon 16: 108,964,180–108,964,312, 133 basesExon 17: 108,964,980–108,965,140, 161 basesExon 18: 108,973,357–108,974,476, 1,120 bases151015185′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.7 kb of the gene's 126.1 kb; 2,604 of those bases code for the protein.

How a genome test reads ARMC2

2

positions in ARMC2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 126.1 kb of ARMC2, introns included, not only the 3.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ARMC2 gene: armadillo repeat containing 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/armc2

Vancouver

Dante Labs. ARMC2 gene: armadillo repeat containing 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/armc2

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