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Gene

IRF1

interferon regulatory factor 1

Summary

Cytogenetic location
5q31.1
Coordinates
Chromosome 5: 132,481,609–132,490,773 (GRCh38)
Exons
10 exons across 9.2 kb
Protein
325 amino acids
Also known as
MAR
MANE Select transcript
ENST00000245414.9NM_002198.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Other Inborn Errors of Immunity

      • Immunodeficiency Disease

        One of 170 genes linked to it

        Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

        • 1 GenCC submitter rates it definitive or strong
        What knowing changes

        HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

    How IRF1 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Stretches short reads find hard
    Chromosome 5, with a bracket where IRF1 sits. IRF1 and 22 genes near it on chromosome 5, from 131,986,191 to 132,986,190.Chromosome 55q31.1p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3132 Mb132.2 Mb132.4 Mb132.6 Mb132.8 Mb: 131,807,143–132,011,637, reverse strandACSL6: 131,949,973–132,012,243, reverse strandACSL6IL3: 132,060,655–132,063,204, forward strandIL3CSF2: 132,073,784–132,076,170, forward strandCSF2P4HA2: 132,190,094–132,295,315, reverse strandP4HA2PDLIM4: 132,257,640–132,273,712, forward strandPDLIM4SLC22A4: 132,293,737–132,344,206, forward strandSLC22A4SLC22A5: 132,369,493–132,395,615, forward strandSLC22A5: 132,410,832–132,646,079, forward strandIRF1: 132,481,609–132,490,773, reverse strandIRF1IL5: 132,541,444–132,556,838, reverse strandIL5RAD50: 132,556,019–132,646,349, forward strandRAD50IL13: 132,656,263–132,661,110, forward strandIL13IL4: 132,673,986–132,682,678, forward strandIL4KIF3A: 132,688,806–132,737,638, reverse strandKIF3ACCNI2: 132,747,319–132,765,178, forward strandCCNI2SEPTIN8: 132,750,138–132,807,241, reverse strandSEPTIN8SOWAHA: 132,813,302–132,816,786, forward strandSOWAHASHROOM1: 132,821,271–132,830,924, reverse strandSHROOM1GDF9: 132,861,181–132,866,884, reverse strandGDF9UQCRQ: 132,866,623–132,868,847, forward strandUQCRQLEAP2: 132,873,444–132,899,343, forward strandLEAP2AFF4: 132,875,395–132,963,931, reverse strandAFF4Diagram of IRF1: 10 exons on the reverse strand of chromosome 5Exon 10: 132,481,609–132,484,075, 2,467 basesExon 9: 132,484,362–132,484,497, 136 basesExon 8: 132,485,667–132,485,716, 50 basesExon 7: 132,486,251–132,486,373, 123 basesExon 6: 132,486,557–132,486,686, 130 basesExon 5: 132,486,795–132,486,844, 50 basesExon 4: 132,486,954–132,487,130, 177 basesExon 3: 132,487,926–132,488,025, 100 basesExon 2: 132,489,392–132,489,483, 92 basesExon 1: 132,490,545–132,490,773, 229 bases109876543215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3.6 kb of the gene's 9.2 kb; 978 of those bases code for the protein.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). IRF1 gene: interferon regulatory factor 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/irf1

    Vancouver

    Dante Labs. IRF1 gene: interferon regulatory factor 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/irf1

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