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Gene

IGSF3

immunoglobulin superfamily member 3

Summary

Cytogenetic location
1p13.1
Coordinates
Chromosome 1: 116,574,408–116,667,733 (GRCh38)
Exons
11 exons across 93.3 kb
Protein
1,194 amino acids
Also known as
V8, EWI-3, MGC117164
MANE Select transcript
ENST00000369486.8NM_001007237.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads IGSF3 yet. The test sequences your whole genome, so your data includes it all the same.

How IGSF3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where IGSF3 sits. IGSF3 and 8 genes near it on chromosome 1, from 116,121,071 to 117,121,070.Chromosome 11p13.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44116.2 Mb116.4 Mb116.6 Mb116.8 Mb117 MbMAB21L3: 116,111,068–116,138,149, forward strandMAB21L3ATP1A1: 116,372,668–116,410,261, forward strandATP1A1CD58: 116,499,485–116,571,061, reverse strandCD58IGSF3: 116,574,408–116,667,733, reverse strandIGSF3CD2: 116,754,370–116,769,229, forward strandCD2PTGFRN: 116,909,870–116,990,358, forward strandPTGFRNCD101: 117,001,721–117,036,552, forward strandCD101TTF2: 117,060,285–117,107,453, forward strandTTF2TRIM45: 117,111,060–117,122,587, reverse strandTRIM45Diagram of IGSF3: 11 exons on the reverse strand of chromosome 1Exon 7: 1 known disease-causing siteExon 11: 116,574,408–116,577,562, 3,155 basesExon 10: 116,579,392–116,579,877, 486 basesExon 9: 116,584,645–116,585,052, 408 basesExon 8: 116,588,694–116,589,104, 411 basesExon 7: 116,599,941–116,600,345, 405 basesExon 6: 116,603,624–116,604,025, 402 basesExon 5: 116,607,942–116,608,331, 390 basesExon 4: 116,613,765–116,614,175, 411 basesExon 3: 116,616,080–116,616,457, 378 basesExon 2: 116,666,284–116,666,956, 673 basesExon 1: 116,667,618–116,667,733, 116 bases1110515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.2 kb of the gene's 93.3 kb; 3,585 of those bases code for the protein.

How a genome test reads IGSF3

1

position in IGSF3 where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (100%) falls in a region short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (1 site)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 93.3 kb of IGSF3, introns included, not only the 7.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IGSF3 gene: immunoglobulin superfamily member 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/igsf3

Vancouver

Dante Labs. IGSF3 gene: immunoglobulin superfamily member 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/igsf3

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