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Gene

NECTIN4

nectin cell adhesion molecule 4

Summary

Cytogenetic location
1q23.3
Coordinates
Chromosome 1: 161,070,998–161,089,558 (GRCh38)
Exons
9 exons across 18.6 kb
Protein
510 amino acids
Inheritance
Autosomal recessive
Also known as
nectin-4, PRR4, LNIR
Previous symbols
PVRL4
MANE Select transcript
ENST00000368012.4NM_030916.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Ectodermal Dysplasias

    • Ectodermal dysplasia-syndactyly syndrome 1Autosomal recessive

      A NECTIN4 disorder with sparse hair, tooth anomalies and fused fingers or toes.

      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How NECTIN4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where NECTIN4 sits. NECTIN4 and 34 genes near it on chromosome 1, from 160,580,278 to 161,580,277.Chromosome 11q23.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44160.6 Mb160.8 Mb161 Mb161.2 Mb161.4 MbSLAMF1: 160,608,100–160,647,056, reverse strandSLAMF1CD48: 160,678,746–160,711,831, reverse strandCD48SLAMF7: 160,739,057–160,754,821, forward strandSLAMF7LY9: 160,796,071–160,828,601, forward strandLY9CD244: 160,829,075–160,862,904, reverse strandCD244ITLN1: 160,876,539–160,893,012, reverse strandITLN1ITLN2: 160,944,266–160,954,889, reverse strandITLN2F11R: 160,985,714–161,023,123, reverse strand: 160,997,957–161,038,962, reverse strandTSTD1: 161,037,619–161,039,118, reverse strandTSTD1USF1: 161,039,249–161,045,982, reverse strandUSF1ARHGAP30: 161,046,944–161,069,970, reverse strandARHGAP30NECTIN4: 161,070,998–161,089,558, reverse strandNECTIN4KLHDC9: 161,098,343–161,100,346, forward strandKLHDC9PFDN2: 161,100,556–161,118,070, reverse strandPFDN2NIT1: 161,118,082–161,125,812, forward strandNIT1DEDD: 161,120,957–161,133,280, reverse strandUFC1: 161,152,776–161,159,368, forward strandUFC1USP21: 161,159,450–161,165,723, forward strandUSP21PPOX: 161,165,837–161,178,576, forward strandPPOXB4GALT3: 161,171,304–161,178,652, reverse strandADAMTS4: 161,184,302–161,200,509, reverse strandNDUFS2: 161,197,104–161,214,723, forward strandFCER1G: 161,215,175–161,220,709, forward strandFCER1GAPOA2: 161,222,290–161,227,266, reverse strandAPOA2TOMM40L: 161,225,939–161,233,755, forward strandNR1I3: 161,228,775–161,238,276, reverse strandNR1I3PCP4L1: 161,258,136–161,285,450, forward strandPCP4L1MPZ: 161,304,735–161,309,974, reverse strandMPZSDHC: 161,314,352–161,363,774, forward strandSDHCCFAP126: 161,364,733–161,367,885, reverse strandCFAP126FCGR2A: 161,505,415–161,524,013, forward strandFCGR2AHSPA6: 161,524,540–161,526,894, forward strandHSPA6FCGR3A: 161,541,738–161,550,968, reverse strandFCGR3A: 161,544,807–161,631,456, reverse strandDiagram of NECTIN4: 9 exons on the reverse strand of chromosome 1Exon 9: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 9: 161,070,998–161,072,885, 1,888 basesExon 8: 161,073,225–161,073,299, 75 basesExon 7: 161,073,720–161,073,795, 76 basesExon 6: 161,074,217–161,074,373, 157 basesExon 5: 161,074,611–161,074,759, 149 basesExon 4: 161,076,355–161,076,475, 121 basesExon 3: 161,077,453–161,077,743, 291 basesExon 2: 161,079,590–161,079,949, 360 basesExon 1: 161,089,218–161,089,558, 341 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.5 kb of the gene's 18.6 kb; 1,533 of those bases code for the protein.

How a genome test reads NECTIN4

3

positions in NECTIN4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.6 kb of NECTIN4, introns included, not only the 3.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NECTIN4 gene: nectin cell adhesion molecule 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/nectin4

Vancouver

Dante Labs. NECTIN4 gene: nectin cell adhesion molecule 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nectin4

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