Trait

Acne inversa

A chronic skin condition involving the inflammation of the apocrine sweat glands, forming pimple-like bumps known as abscesses.

HPO HP:0040154

Also called: Hidradenitis suppurativa, Pyoderma fistulans significa, Smoker's boils, Verneuil's disease
Body system: Abnormality of the immune system Abnormality of the integument

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13 genes linked to Acne inversa

Changes in these genes cause rare conditions in which Acne inversa is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
HYOU1hypoxia up-regulated 1	Always	In 1 condition
KDF1keratinocyte differentiation factor 1	Always	In 1 condition
PSENENpresenilin enhancer, gamma-secretase subunit	Always	In 2 conditions
MEFVMEFV innate immunity regulator, pyrin	Often (30–79%)	In 2 conditions
IKBKBinhibitor of nuclear factor kappa B kinase subunit beta	Sometimes (5–29%)	In 1 condition
KRT5keratin 5	Sometimes (5–29%)	In 1 condition
POFUT1protein O-fucosyltransferase 1	Sometimes (5–29%)	In 1 condition
POGLUT1protein O-glucosyltransferase 1	Sometimes (5–29%)	In 1 condition
PTPN6protein tyrosine phosphatase non-receptor type 6	Sometimes (5–29%)	In 1 condition
GJB2gap junction protein beta 2	Rarely (1–4%)	In 1 condition
GJB6gap junction protein beta 6	Rarely (1–4%)	In 1 condition
NCSTNnicastrin	Not recorded	In 1 condition
PSEN1presenilin 1	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Acne

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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