Trait
Yellowish cloudy center of lens
Clinical name: Nuclear cataract
A nuclear cataract is an opacity or clouding that develops in the lens nucleus. That is, a nuclear cataract is one that is located in the center of the lens. The nucleus tends to darken changing from clear to yellow and sometimes brown.
Summary
- Also called
- Yellowish cloudy centre of lens
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
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Get my Genome Test29 genes linked to Yellowish cloudy center of lens
Changes in these genes cause rare conditions in which Yellowish cloudy center of lens is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CRYBA1crystallin beta A1 | Always | In 1 condition |
| CRYBA4crystallin beta A4 | Always | In 1 condition |
| CRYBB3crystallin beta B3 | Always | In 1 condition |
| CRYGScrystallin gamma S | Always | In 1 condition |
| FDXRferredoxin reductase | Always | In 1 condition |
| GJA8gap junction protein alpha 8 | Always | In 1 condition |
| NHEJ1non-homologous end joining factor 1 | Always | In 1 condition |
| NHSNHS actin remodeling regulator | Always | In 2 conditions |
| SLC2A1solute carrier family 2 member 1 | Always | In 1 condition |
| UBAP1Lubiquitin associated protein 1 like | Always | In 1 condition |
| EFEMP1EGF-like fibulin extracellular matrix protein 1 | Often (30–79%) | In 1 condition |
| GALK1galactokinase 1 | Often (30–79%) | In 1 condition |
| MVKmevalonate kinase | Often (30–79%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Sometimes (5–29%) | In 1 condition |
| IMPG2interphotoreceptor matrix proteoglycan 2 | Sometimes (5–29%) | In 1 condition |
| LIM2lens intrinsic membrane protein 2 | Sometimes (5–29%) | In 1 condition |
| NR2E3nuclear receptor subfamily 2 group E member 3 | Sometimes (5–29%) | In 1 condition |
| ZNF408zinc finger protein 408 | Sometimes (5–29%) | In 1 condition |
| PRG4proteoglycan 4 | Rarely (1–4%) | In 1 condition |
| BFSP1beaded filament structural protein 1 | Not recorded | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Not recorded | In 1 condition |
| CHMP4Bcharged multivesicular body protein 4B | Not recorded | In 1 condition |
| CRYBB1crystallin beta B1 | Not recorded | In 1 condition |
| CRYGCcrystallin gamma C | Not recorded | In 1 condition |
| FTLferritin light chain | Not recorded | In 1 condition |
| FYCO1FYVE and coiled-coil domain autophagy adaptor 1 | Not recorded | In 1 condition |
| HSF4heat shock transcription factor 4 | Not recorded | In 1 condition |
| MIPmajor intrinsic protein of lens fiber | Not recorded | In 1 condition |
| WFS1wolframin ER transmembrane glycoprotein | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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