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Gene

HPCA

hippocalcin

Summary

Cytogenetic location
1p35.1
Coordinates
Chromosome 1: 32,886,491–32,894,646 (GRCh38)
Exons
4 exons across 8.2 kb
Protein
193 amino acids
Previous symbols
DYT2
MANE Select transcript
ENST00000373467.4NM_002143.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Dystonia, Myotonia, Paroxysmal Dyskinesia

    • Inherited Dystonia

      Umbrella term covering inherited dystonias, including DYT-TOR1A early-onset generalized dystonia, DYT-THAP1, myoclonus-dystonia (SGCE) and KMT2B-related dystonia.

      • 3 GenCC submitters rate it definitive or strong

How HPCA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 1, with a bracket where HPCA sits. HPCA and 19 genes near it on chromosome 1, from 32,390,569 to 33,390,568.Chromosome 11p35.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4432.4 Mb32.6 Mb32.8 Mb33 Mb33.2 MbBSDC1: 32,364,633–32,394,731, reverse strandBSDC1ZBTB8B: 32,465,047–32,496,686, forward strandZBTB8B: 32,465,057–32,600,792, forward strandZBTB8A: 32,539,134–32,605,941, forward strandZBTB8ATSLIG1: 32,599,890–32,651,011, reverse strandTSLIG1RBBP4: 32,651,043–32,705,899, forward strandRBBP4SYNC: 32,679,412–32,703,596, reverse strandSYNCNHSL3: 32,741,696–32,774,970, forward strandNHSL3YARS1: 32,774,776–32,818,031, reverse strandYARS1S100PBP: 32,816,408–32,858,879, forward strandS100PBPFNDC5: 32,862,268–32,872,482, reverse strandFNDC5HPCA: 32,886,491–32,894,646, forward strandHPCATMEM54: 32,894,593–32,901,440, reverse strandTMEM54RNF19B: 32,929,036–32,964,938, reverse strandRNF19BAK2: 33,006,560–33,080,996, reverse strandAK2AZIN2: 33,081,104–33,123,492, forward strandAZIN2TRIM62: 33,145,399–33,182,092, reverse strandTRIM62ZNF362: 33,256,273–33,300,719, forward strandZNF362A3GALT2: 33,306,766–33,321,098, reverse strandA3GALT2PHC2: 33,321,755–33,431,095, reverse strandPHC2Diagram of HPCA: 4 exons on the forward strand of chromosome 1Exon 1: 32,886,491–32,886,515, 25 basesExon 2: 32,888,878–32,889,276, 399 basesExon 3: 32,893,524–32,893,629, 106 basesExon 4: 32,893,765–32,894,646, 882 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.4 kb of the gene's 8.2 kb; 582 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HPCA gene: hippocalcin. Retrieved 16 October 2026, from https://dantelabs.com/genes/hpca

Vancouver

Dante Labs. HPCA gene: hippocalcin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/hpca

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