Trait

Multifocal seizures

Seizures that start from several different areas of the brain (i.e., with multiple ictal onset locations).

Also called: Multifocal onset seizures
Body system: Abnormality of the nervous system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/multifocal-seizures.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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24 genes linked to Multifocal seizures

Changes in these genes cause rare conditions in which Multifocal seizures is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ARV1ARV1 fatty acid homeostasis modulator	Always	In 1 condition
ATP6V0CATPase H+ transporting V0 subunit c	Always	In 1 condition
GCSHglycine cleavage system protein H	Always	In 1 condition
NECAP1NECAP endocytosis associated 1	Always	In 1 condition
PIGQphosphatidylinositol glycan anchor biosynthesis class Q	Always	In 1 condition
SMC1Astructural maintenance of chromosomes 1A	Always	In 1 condition
UNC13Aunc-13 homolog A	Always	In 1 condition
WARS2tryptophanyl tRNA synthetase 2, mitochondrial	Always	In 2 conditions
CARS2cysteinyl-tRNA synthetase 2, mitochondrial	Often (30–79%)	In 1 condition
DEPDC5DEP domain containing 5, GATOR1 subcomplex subunit	Often (30–79%)	In 1 condition
DNM1dynamin 1	Often (30–79%)	In 1 condition
PIGSphosphatidylinositol glycan anchor biosynthesis class S	Often (30–79%)	In 1 condition
SPOUT1SPOUT domain containing methyltransferase 1	Often (30–79%)	In 1 condition
TBCKTBC1 domain containing kinase	Often (30–79%)	In 1 condition
TFE3transcription factor binding to IGHM enhancer 3	Often (30–79%)	In 1 condition
ADPRSADP-ribosylserine hydrolase	Sometimes (5–29%)	In 1 condition
ATP1A3ATPase Na+/K+ transporting subunit alpha 3	Sometimes (5–29%)	In 1 condition
FRRS1Lferric chelate reductase 1 like	Sometimes (5–29%)	In 1 condition
PPP2R5Dprotein phosphatase 2 regulatory subunit B'delta	Sometimes (5–29%)	In 1 condition
TANGO2transport and golgi organization 2 homolog	Sometimes (5–29%)	In 1 condition
BRAT1BRCA1 associated ATM activator 1	Not recorded	In 1 condition
CDKL5cyclin dependent kinase like 5	Not recorded	In 1 condition
GALNT2polypeptide N-acetylgalactosaminyltransferase 2	Not recorded	In 1 condition
SLC13A5solute carrier family 13 member 5	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Seizure affecting one half of brain

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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