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Gene

SYCP2L

synaptonemal complex protein 2 like

Summary

Cytogenetic location
6p24.2
Coordinates
Chromosome 6: 10,887,052–10,974,309 (GRCh38)
Exons
30 exons across 87.3 kb
Protein
812 amino acids
Also known as
dJ62D2.1, NO145
Previous symbols
C6orf177
MANE Select transcript
ENST00000283141.11NM_001040274.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Female Infertility

    • Diminished or absent ability of a female to achieve conception.

      • 1 GenCC submitter rates it definitive or strong

How SYCP2L is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where SYCP2L sits. SYCP2L and 13 genes near it on chromosome 6, from 10,430,681 to 11,430,680.Chromosome 66p24.2p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2710.6 Mb10.8 Mb11 Mb11.2 Mb11.4 MbGCNT2: 10,492,223–10,629,377, forward strandGCNT2C6orf52: 10,671,283–10,694,797, reverse strandC6orf52PAK1IP1: 10,694,633–10,711,168, forward strandPAK1IP1TMEM14C: 10,722,915–10,731,141, forward strandTMEM14CTMEM14B: 10,747,695–10,866,590, forward strandTMEM14B: 10,747,794–10,930,423, forward strandMAK: 10,762,723–10,838,553, reverse strandMAKGCM2: 10,873,223–10,882,041, reverse strandGCM2SYCP2L: 10,887,052–10,974,309, forward strandSYCP2LELOVL2: 10,980,742–11,044,446, reverse strandELOVL2SMIM13: 11,093,820–11,138,733, forward strandSMIM13KANGD1: 11,093,834–11,138,733, forward strandKANGD1ERVFRD-1: 11,102,324–11,111,845, reverse strandERVFRD-1NEDD9: 11,181,524–11,382,348, reverse strandNEDD9Diagram of SYCP2L: 30 exons on the forward strand of chromosome 6Exon 3: 1 known disease-causing siteExon 1: 10,887,052–10,887,135, 84 basesExon 2: 10,891,513–10,891,581, 69 basesExon 3: 10,893,867–10,894,004, 138 basesExon 4: 10,894,085–10,894,204, 120 basesExon 5: 10,898,011–10,898,115, 105 basesExon 6: 10,898,824–10,898,848, 25 basesExon 7: 10,902,677–10,902,762, 86 basesExon 8: 10,902,875–10,902,963, 89 basesExon 9: 10,906,020–10,906,054, 35 basesExon 10: 10,907,542–10,907,684, 143 basesExon 11: 10,910,148–10,910,200, 53 basesExon 12: 10,910,824–10,910,869, 46 basesExon 13: 10,912,673–10,912,765, 93 basesExon 14: 10,912,867–10,912,927, 61 basesExon 15: 10,924,496–10,924,641, 146 basesExon 16: 10,926,339–10,926,432, 94 basesExon 17: 10,927,240–10,927,367, 128 basesExon 18: 10,928,403–10,928,450, 48 basesExon 19: 10,930,370–10,930,514, 145 basesExon 20: 10,931,440–10,931,489, 50 basesExon 21: 10,935,058–10,935,187, 130 basesExon 22: 10,942,459–10,942,529, 71 basesExon 23: 10,942,677–10,942,746, 70 basesExon 24: 10,955,116–10,955,217, 102 basesExon 25: 10,956,136–10,956,242, 107 basesExon 26: 10,958,784–10,958,875, 92 basesExon 27: 10,961,305–10,961,404, 100 basesExon 28: 10,961,500–10,961,558, 59 basesExon 29: 10,963,782–10,963,843, 62 basesExon 30: 10,973,952–10,974,309, 358 bases1246810121416182022242628305′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.9 kb of the gene's 87.3 kb; 2,439 of those bases code for the protein.

How a genome test reads SYCP2L

2

positions in SYCP2L where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 87.3 kb of SYCP2L, introns included, not only the 2.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SYCP2L gene: synaptonemal complex protein 2 like. Retrieved 17 October 2026, from https://dantelabs.com/genes/sycp2l

Vancouver

Dante Labs. SYCP2L gene: synaptonemal complex protein 2 like [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/sycp2l

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