Trait
Abnormal circulating lipid concentration
Any deviation from the normal concentration of lipid in the blood circulation.
Summary
- Also called
- Abnormal lipid level
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
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Get my Genome Test40 genes linked to Abnormal circulating lipid concentration
Changes in these genes cause rare conditions in which Abnormal circulating lipid concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCC8ATP binding cassette subfamily C member 8 | Always | In 1 condition |
| LAMB1laminin subunit beta 1 | Always | In 1 condition |
| ABCA1ATP binding cassette subfamily A member 1 | Very often (80–99%) | In 1 condition |
| APOA1apolipoprotein A1 | Very often (80–99%) | In 1 condition |
| SLC25A13solute carrier family 25 member 13 | Very often (80–99%) | In 1 condition |
| GLAgalactosidase alpha | Often (30–79%) | In 1 condition |
| IL12Ainterleukin 12A | Often (30–79%) | In 1 condition |
| IL12RB1interleukin 12 receptor subunit beta 1 | Often (30–79%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 1 condition |
| MMEL1membrane metalloendopeptidase like 1 | Often (30–79%) | In 1 condition |
| POU2AF1POU class 2 homeobox associating factor 1 | Often (30–79%) | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| SPIBSpi-B transcription factor | Often (30–79%) | In 1 condition |
| TBCKTBC1 domain containing kinase | Often (30–79%) | In 1 condition |
| TNFSF15TNF superfamily member 15 | Often (30–79%) | In 1 condition |
| TNPO3transportin 3 | Often (30–79%) | In 1 condition |
| ARandrogen receptor | Sometimes (5–29%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Sometimes (5–29%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Sometimes (5–29%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Sometimes (5–29%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Sometimes (5–29%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Sometimes (5–29%) | In 1 condition |
| ELNelastin | Sometimes (5–29%) | In 1 condition |
| FBN1fibrillin 1 | Sometimes (5–29%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Sometimes (5–29%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Sometimes (5–29%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Sometimes (5–29%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Sometimes (5–29%) | In 1 condition |
| HRHR lysine demethylase and nuclear receptor corepressor | Sometimes (5–29%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Sometimes (5–29%) | In 1 condition |
| METTL27methyltransferase like 27 | Sometimes (5–29%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Sometimes (5–29%) | In 1 condition |
| RFC2replication factor C subunit 2 | Sometimes (5–29%) | In 1 condition |
| STX1Asyntaxin 1A | Sometimes (5–29%) | In 1 condition |
| TBL2transducin beta like 2 | Sometimes (5–29%) | In 1 condition |
| TMEM270transmembrane protein 270 | Sometimes (5–29%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Sometimes (5–29%) | In 1 condition |
| LIPElipase E, hormone sensitive type | Not recorded | In 1 condition |
| LMNB2lamin B2 | Not recorded | In 1 condition |
| XRCC4X-ray repair cross complementing 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Elevated lipids in blood45 genes
- Abnormality of cholesterol metabolism6 genes
- Abnormal circulating fatty acid concentration2 genes
- Elevated circulating C-triol concentration2 genes
- Elevated circulating sitosterol concentration2 genes
- Elevated circulating dimethyl sterol concentration1 gene
- Elevated circulating lysosphingomyelin concentration1 gene
- Elevated circulating methysterol concentration1 gene
- Elevated circulating monomethyl sterol concentration1 gene
- Hyperapobetalipoproteinemia1 gene
- Increased circulating farnesol concentration1 gene
- Abnormal circulating beta-carotene concentration
- Abnormal circulating phospholipid concentration
- Hypolipidemia
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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