Trait
Increased circulating hemoglobin concentration
Concentration of hemoglobin in the blood circulation above the upper limit of normal.
Summary
- Also called
- Increased haemoglobin, Increased haemoglobin concentration, Increased Hb, Increased Hb concentration, Increased hemoglobin, Increased hemoglobin concentration
Reference genomeGRCh38hg38
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Get my Genome Test14 genes linked to Increased circulating hemoglobin concentration
Changes in these genes cause rare conditions in which Increased circulating hemoglobin concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BPGMbisphosphoglycerate mutase | Always | In 1 condition |
| EPAS1endothelial PAS domain protein 1 | Always | In 1 condition |
| EPORerythropoietin receptor | Always | In 1 condition |
| HBBhemoglobin subunit beta | Always | In 1 condition |
| JAK2Janus kinase 2 | Always | In 2 conditions |
| SH2B3SH2B adaptor protein 3 | Always | In 1 condition |
| VHLvon Hippel-Lindau tumor suppressor | Always | In 1 condition |
| KCNN4potassium calcium-activated channel subfamily N member 4 | Sometimes (5–29%) | In 1 condition |
| PIEZO1piezo type mechanosensitive ion channel component 1 (Er blood group) | Sometimes (5–29%) | In 1 condition |
| SLC4A1solute carrier family 4 member 1 (Diego blood group) | Sometimes (5–29%) | In 1 condition |
| EGLN1egl-9 family hypoxia inducible factor 1 | Not recorded | In 1 condition |
| EPOerythropoietin | Not recorded | In 1 condition |
| HBA1hemoglobin subunit alpha 1 | Not recorded | In 1 condition |
| HBA2hemoglobin subunit alpha 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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