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Trait

Melorheostosis

Regions of sclerosing hyperostosis in the cortex of long bones, which might have a radiologic appearance of dripping candle wax.

HPO HP:6000817

Summary

Body system
Abnormality of the musculoskeletal system

2 genes linked to Melorheostosis

Changes in these genes cause rare conditions in which Melorheostosis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
LEMD3LEM domain containing 3Not recordedIn 1 condition
MAP2K1mitogen-activated protein kinase kinase 1Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal shape of long bone

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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