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Gene

SEMA6B

semaphorin 6B

Summary

Cytogenetic location
19p13.3
Coordinates
Chromosome 19: 4,542,593–4,559,684 (GRCh38)
Exons
17 exons across 17.1 kb
Protein
888 amino acids
Also known as
semaZ, SEMA-VIB, SEM-SEMA-Z
Previous symbols
SEMAN
MANE Select transcript
ENST00000586582.6NM_032108.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong

    • Intellectual Disability

      • One of 233 genes linked to it

        • 1 GenCC submitter rates it definitive or strong

    How SEMA6B is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 19, with a bracket where SEMA6B sits. SEMA6B and 29 genes near it on chromosome 19, from 4,051,139 to 5,051,138.Chromosome 1919p13.3p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.434.2 Mb4.4 Mb4.6 Mb4.8 Mb5 MbZBTB7A: 4,041,419–4,067,636, reverse strandZBTB7AMAP2K2: 4,090,316–4,124,238, reverse strandMAP2K2CREB3L3: 4,152,949–4,173,057, forward strandCREB3L3SIRT6: 4,174,104–4,182,604, reverse strandSIRT6ANKRD24: 4,182,630–4,224,818, forward strandANKRD24EBI3: 4,229,267–4,238,167, forward strandEBI3YJU2: 4,247,062–4,269,091, forward strandYJU2SHD: 4,279,013–4,290,728, forward strandSHDTMIGD2: 4,292,227–4,302,431, reverse strandTMIGD2FSD1: 4,304,587–4,323,844, forward strandFSD1STAP2: 4,324,040–4,342,786, reverse strandSTAP2MPND: 4,343,527–4,360,086, forward strandMPNDSH3GL1: 4,360,367–4,400,573, reverse strandSH3GL1CHAF1A: 4,402,522–4,445,018, forward strandCHAF1AUBXN6: 4,444,999–4,457,794, reverse strandUBXN6HDGFL2: 4,472,244–4,502,225, forward strandHDGFL2PLIN4: 4,502,182–4,520,379, reverse strandPLIN5: 4,522,527–4,535,285, reverse strandPLIN5: 4,528,427–4,540,067, reverse strandLRG1: 4,536,402–4,540,104, reverse strandLRG1SEMA6B: 4,542,593–4,559,684, reverse strandSEMA6BTIPE1: 4,639,503–4,655,568, forward strandTIPE1MYDGF: 4,641,374–4,670,403, reverse strandMYDGFDPP9: 4,674,341–4,724,673, reverse strandDPP9FEM1A: 4,791,734–4,801,273, forward strandFEM1ATICAM1: 4,815,932–4,831,749, reverse strandTICAM1PLIN3: 4,838,334–4,867,717, reverse strandPLIN3ARRDC5: 4,890,437–4,902,948, reverse strandARRDC5UHRF1: 4,903,080–4,962,154, forward strandUHRF1KDM4B: 4,969,106–5,153,611, forward strandKDM4BDiagram of SEMA6B: 17 exons on the reverse strand of chromosome 19Exon 17: 9 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 17: 4,542,593–4,544,529, 1,937 basesExon 16: 4,546,216–4,546,274, 59 basesExon 15: 4,546,392–4,546,469, 78 basesExon 14: 4,548,027–4,548,173, 147 basesExon 13: 4,548,263–4,548,445, 183 basesExon 12: 4,550,123–4,550,272, 150 basesExon 11: 4,550,799–4,550,930, 132 basesExon 10: 4,552,422–4,552,639, 218 basesExon 9: 4,554,388–4,554,476, 89 basesExon 8: 4,554,976–4,555,095, 120 basesExon 7: 4,555,474–4,555,564, 91 basesExon 6: 4,555,988–4,556,089, 102 basesExon 5: 4,556,951–4,557,013, 63 basesExon 4: 4,557,163–4,557,223, 61 basesExon 3: 4,558,026–4,558,149, 124 basesExon 2: 4,558,337–4,558,489, 153 basesExon 1: 4,559,530–4,559,684, 155 bases1716141210864215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3.9 kb of the gene's 17.1 kb; 2,667 of those bases code for the protein.

    How a genome test reads SEMA6B

    13

    positions in SEMA6B where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 17.1 kb of SEMA6B, introns included, not only the 3.9 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). SEMA6B gene: semaphorin 6B. Retrieved 17 October 2026, from https://dantelabs.com/genes/sema6b

    Vancouver

    Dante Labs. SEMA6B gene: semaphorin 6B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/sema6b

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