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Gene

GRIN2B

glutamate ionotropic receptor NMDA type subunit 2B

Summary

Cytogenetic location
12p13.1
Coordinates
Chromosome 12: 13,537,337–13,981,602 (GRCh38)
Exons
14 exons across 444.3 kb
Protein
1,484 amino acids
Also known as
GluN2B, NR2B
Previous symbols
NMDAR2B
MANE Select transcript
ENST00000609686.4NM_000834.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 2 GenCC submitters rate it definitive or strong

    • Intellectual Disability

      • One of 233 genes linked to it

        • 2 GenCC submitters rate it definitive or strong

    How GRIN2B is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 12, with a bracket where GRIN2B sits. GRIN2B and 6 genes near it on chromosome 12, from 13,093,071 to 14,425,868.Chromosome 1212p13.1p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3313.2 Mb13.4 Mb13.6 Mb13.8 Mb14 Mb14.2 Mb14.4 MbFAM234B: 13,044,185–13,142,521, forward strandFAM234BGSG1: 13,083,532–13,103,683, reverse strandGSG1: 13,088,784–13,103,484, reverse strandEMP1: 13,196,529–13,219,941, forward strandEMP1GRIN2B: 13,537,337–13,981,602, reverse strandGRIN2B: 13,979,928–13,980,895, reverse strandATF7IP: 14,365,439–14,502,931, forward strandATF7IPDiagram of GRIN2B: 14 exons on the reverse strand of chromosome 12Exon 14: 17 known disease-causing sitesExon 13: 34 known disease-causing sitesExon 12: 11 known disease-causing sitesExon 11: 19 known disease-causing sitesExon 10: 28 known disease-causing sitesExon 9: 7 known disease-causing sitesExon 8: 19 known disease-causing sitesExon 7: 13 known disease-causing sitesExon 6: 10 known disease-causing sitesExon 5: 5 known disease-causing sitesExon 4: 9 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 14: 13,537,337–13,564,639, 27,303 basesExon 13: 13,567,025–13,567,263, 239 basesExon 12: 13,569,830–13,570,017, 188 basesExon 11: 13,571,804–13,571,964, 161 basesExon 10: 13,608,603–13,608,832, 230 basesExon 9: 13,611,725–13,611,850, 126 basesExon 8: 13,615,114–13,615,267, 154 basesExon 7: 13,615,493–13,615,664, 172 basesExon 6: 13,616,455–13,616,657, 203 basesExon 5: 13,675,745–13,675,859, 115 basesExon 4: 13,753,317–13,753,915, 599 basesExon 3: 13,865,798–13,866,226, 429 basesExon 2: 13,979,928–13,980,356, 429 basesExon 1: 13,981,342–13,981,602, 261 bases1410515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 30.6 kb of the gene's 444.3 kb; 4,455 of those bases code for the protein.

    How a genome test reads GRIN2B

    183

    positions in GRIN2B where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 444.3 kb of GRIN2B, introns included, not only the 30.6 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). GRIN2B gene: glutamate ionotropic receptor NMDA type subunit 2B. Retrieved 16 October 2026, from https://dantelabs.com/genes/grin2b

    Vancouver

    Dante Labs. GRIN2B gene: glutamate ionotropic receptor NMDA type subunit 2B [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/grin2b

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