Traits

Traits linked to EDA

ectodysplasin A

The Human Phenotype Ontology links 77 traits to EDA, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Absence of upper jaw bones	Always
Absent eyebrow	Always
Dark circles around the eyes	Always
Depressed nasal bridge	Always
Failure of development of between one and six teeth	Always
Failure of development of more than six teeth	Always
Full lips	Always
Missing lateral incisor	Always
Prominent forehead	Always
Wrinkles around the eyes	Always
Absence of molar	Very often (80–99%)
Absence of premolar	Very often (80–99%)
Chewing difficulties	Very often (80–99%)
Decreased size of tooth	Very often (80–99%)
Delayed eruption of teeth	Very often (80–99%)
Drooping lower lip	Very often (80–99%)
Drooping upper lip	Very often (80–99%)
Flat nose	Very often (80–99%)
Sparse or absent eyebrows	Very often (80–99%)
Absence of six year molar	Often (30–79%)
Absence of upper lateral incisor	Often (30–79%)
Absent central incisor	Often (30–79%)
Bad bite	Often (30–79%)
Decreased length of dental roots	Often (30–79%)
Delayed eruption of permanent teeth	Often (30–79%)
Frontal bossing	Often (30–79%)
Widely spaced teeth	Often (30–79%)
Abnormality of canine	Sometimes (5–29%)
Abnormality of dental shape	Sometimes (5–29%)
Abnormality of shape of baby molar	Sometimes (5–29%)
Absence of lower premolar	Sometimes (5–29%)
Cleft of the mouth	Sometimes (5–29%)
Decreased size of teeth	Sometimes (5–29%)
Outward turned lips	Sometimes (5–29%)
Peg-shaped maxillary lateral incisors	Sometimes (5–29%)
Short face	Sometimes (5–29%)
Taurodontia	Sometimes (5–29%)
Thin dental enamel	Sometimes (5–29%)
Abnormality of lining of mouth	Not recorded
Absence of a tooth	Not recorded
Absent eyelashes	Not recorded
Cone shaped tooth	Not recorded
Decreased number of teeth	Not recorded
Decreased size of maxilla	Not recorded
Failure of development of all teeth	Not recorded
Nasal inflammation	Not recorded
Prominent brow	Not recorded
Short chin	Not recorded
Short nose	Not recorded
Sparse eyebrow	Not recorded
Sparse eyelashes	Not recorded
Underdeveloped tissue around nostril	Not recorded

Abnormality of the integument

Trait	How often it is seen
Decreased ability to sweat	Always
Dry skin	Always
Fine hair	Always
Sparse body hair	Always
Sparse hair	Always
Aplasia/Hypoplasia of the eccrine sweat glands	Not recorded
Brittle hair	Not recorded
Hypoplastic-absent sebaceous glands	Not recorded
Lack of sweating	Not recorded
Soft skin	Not recorded
Spoon-shaped nails	Not recorded
Thin skin	Not recorded

Laboratory abnormality

Trait	How often it is seen
Fever	Always
Type 1 diabetes	Sometimes (5–29%)
Heat intolerance	Not recorded

Abnormality of the breast

Trait	How often it is seen
Absent nipple	Not recorded
Small nipples	Not recorded

Abnormality of the voice

Trait	How often it is seen
Hoarse voice	Not recorded
Inability to produce voice sounds	Not recorded

Abnormality of limbs

Trait	How often it is seen
Short outermost finger bone	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Constipation	Always

Abnormality of the endocrine system

Trait	How often it is seen
Anterior hypopituitarism	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Eczema	Not recorded

Abnormality of the respiratory system

Trait	How often it is seen
Breathing difficulties	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to EDA and how often each is seen. Find out more at hpo.jax.org.

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