Traits

Traits linked to DCC

DCC netrin 1 receptor

The Human Phenotype Ontology links 86 traits to DCC, by body system: features seen in people with one of the gene's rare conditions.

DCC

Abnormality of the nervous system

Trait	How often it is seen
Abnormality of the anterior commissure	Always
Absent hippocampal commissure	Always
Agenesis of corpus callosum	Always
Global developmental delay	Always
Hypoplasia of the pons	Always
Midline brainstem cleft	Always
Abnormal corticospinal tract morphology	Often (30–79%)
Abnormality of movement	Often (30–79%)
Clumsiness	Often (30–79%)
Cognitive impairment	Often (30–79%)
Delayed speech and language development	Often (30–79%)
Fusion of the left and right thalami	Often (30–79%)
Hand mirror movements	Often (30–79%)
Intellectual disability	Often (30–79%)
Interhemispheric cyst	Often (30–79%)
Poor fine motor coordination	Often (30–79%)
Abnormal gait	Sometimes (5–29%)
Ataxia	Sometimes (5–29%)
Difficulty articulating speech	Sometimes (5–29%)
Dysgenesis of the hippocampus	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)
Increased reflexes	Sometimes (5–29%)
Leg paralysis	Sometimes (5–29%)
Specific learning disability	Sometimes (5–29%)
Too much cerebrospinal fluid in the brain	Sometimes (5–29%)
Tremor	Sometimes (5–29%)
Unsteady walk	Sometimes (5–29%)
Weakness of one side of body	Sometimes (5–29%)
Cerebral palsy	Rarely (1–4%)
Intellectual disability, mild	Rarely (1–4%)

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormal erection	Very often (80–99%)
Decreased fertility	Very often (80–99%)
Decreased testicular size	Very often (80–99%)
Short penis	Very often (80–99%)
Underdeveloped penis	Very often (80–99%)
Undescended testes	Often (30–79%)
Abnormal morphology of female internal genitalia	Sometimes (5–29%)
Absent kidney	Sometimes (5–29%)
Dyspareunia	Sometimes (5–29%)
Primary amenorrhea	Sometimes (5–29%)
Cancer starting in small tubes in kidneys	Not recorded
Transitional cell carcinoma of the bladder	Not recorded
Uterine leiomyosarcoma	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Hunched back	Very often (80–99%)
Scoliosis	Very often (80–99%)
Delayed bone maturation	Often (30–79%)
Low muscle tone	Often (30–79%)
Low solidness and mass of the bones	Often (30–79%)
Muscle tissue disease	Often (30–79%)
Tired easily	Often (30–79%)
Abnormal skeletal development	Sometimes (5–29%)
Muscle weakness	Sometimes (5–29%)
Recurrent fractures	Sometimes (5–29%)
Fused neck	Rarely (1–4%)

Abnormality of the eye

Trait	How often it is seen
Horizontal supranuclear gaze palsy	Very often (80–99%)
Cross-eyed	Often (30–79%)
Duane anomaly	Often (30–79%)
Involuntary, rapid, rhythmic eye movements	Often (30–79%)
Visual impairment	Often (30–79%)
Abnormal color vision	Sometimes (5–29%)
Drooping upper eyelid	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Hyposmia	Very often (80–99%)
Lost smell	Very often (80–99%)
Abnormally small head	Often (30–79%)
Short neck	Often (30–79%)
Cleft palate	Sometimes (5–29%)
Decreased number of teeth	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Colon cancer	Not recorded
Esophageal carcinoma	Not recorded
Hereditary nonpolyposis colorectal carcinoma	Not recorded
Stomach tumor	Not recorded

Abnormality of the endocrine system

Trait	How often it is seen
Anterior hypopituitarism	Very often (80–99%)
Delayed puberty	Very often (80–99%)
Gonadotropin-releasing hormone deficiency	Very often (80–99%)
Hypogonadotropic hypogonadism	Very often (80–99%)

Abnormality of limbs

Trait	How often it is seen
Dropped arches	Sometimes (5–29%)
High-arched foot	Sometimes (5–29%)

Abnormality of the breast

Trait	How often it is seen
Underdeveloped breasts	Often (30–79%)
Enlarged male breast	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Proportionate short stature	Often (30–79%)
Obesity	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal cardiovascular system morphology	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Ichthyosis	Sometimes (5–29%)

Abnormality of the voice

Trait	How often it is seen
Abnormality of the voice	Often (30–79%)

Constitutional symptom

Trait	How often it is seen
Muscle ache	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DCC and how often each is seen. Find out more at hpo.jax.org.

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