Traits

Traits linked to CDSN

corneodesmosin

The Human Phenotype Ontology links 29 traits to CDSN, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Itching	Always
Scaling skin	Always
Fine hair	Very often (80–99%)
Brittle hair	Often (30–79%)
Hyperkeratosis	Often (30–79%)
Parakeratosis	Often (30–79%)
Thickening of upper layer of skin	Often (30–79%)
Detachment of nail	Sometimes (5–29%)
Poor nail formation	Sometimes (5–29%)
Abnormality of the axillary hair	Not recorded
Abnormality of the nail	Not recorded
Abnormality of the pubic hair	Not recorded
Absent facial hair	Not recorded
Cleavage at junction of stratum corneum and stratum granulosum	Not recorded
Generalized hypotrichosis	Not recorded
Lack of sweating or excessive sweating	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Sparse scalp hair	Always
Slow-growing scalp hair	Very often (80–99%)
Absence of scalp hair	Often (30–79%)
Hay fever	Sometimes (5–29%)
Abnormal dentition	Not recorded
Abnormal eyelashes	Not recorded
Abnormality of the eyebrow	Not recorded

Abnormality of the immune system

Trait	How often it is seen
Red scaly skin caused by inflammatory skin disease	Always
Asthma	Sometimes (5–29%)
Baby eczema	Sometimes (5–29%)

Abnormal cellular phenotype

Trait	How often it is seen
Increased circulating IgE concentration	Always

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
High blood eosinophil count	Always

Abnormality of limbs

Trait	How often it is seen
Excessive sweating of palms and soles	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CDSN and how often each is seen. Find out more at hpo.jax.org.

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