Trait
Parakeratosis
Abnormal formation of the keratinocytes of the epidermis characterized by persistence of nuclei, incomplete formation of keratin, and moistness and swelling of the keratinocytes.
Summary
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test34 genes linked to Parakeratosis
Changes in these genes cause rare conditions in which Parakeratosis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DCLRE1CDNA cross-link repair 1C | Always | In 1 condition |
| ELOVL1ELOVL fatty acid elongase 1 | Always | In 1 condition |
| GLSglutaminase | Always | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Always | In 1 condition |
| IRF4interferon regulatory factor 4 | Always | In 1 condition |
| KLK11kallikrein related peptidase 11 | Always | In 1 condition |
| PERPp53 apoptosis effector related to PMP22 | Always | In 1 condition |
| RAG1recombination activating 1 | Always | In 1 condition |
| RAG2recombination activating 2 | Always | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Always | In 1 condition |
| CDSNcorneodesmosin | Often (30–79%) | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Often (30–79%) | In 1 condition |
| KRT5keratin 5 | Often (30–79%) | In 1 condition |
| KRT74keratin 74 | Often (30–79%) | In 1 condition |
| LORICRINloricrin cornified envelope precursor protein | Often (30–79%) | In 2 conditions |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Often (30–79%) | In 2 conditions |
| TGM1transglutaminase 1 | Often (30–79%) | In 2 conditions |
| LDHAlactate dehydrogenase A | Sometimes (5–29%) | In 1 condition |
| NIPAL4NIPA like domain containing 4 | Sometimes (5–29%) | In 1 condition |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Not recorded | In 1 condition |
| CARD14caspase recruitment domain family member 14 | Not recorded | In 2 conditions |
| CLDN1claudin 1 | Not recorded | In 1 condition |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Not recorded | In 1 condition |
| DSPdesmoplakin | Not recorded | In 1 condition |
| FLG2filaggrin 2 | Not recorded | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Not recorded | In 1 condition |
| MVDmevalonate diphosphate decarboxylase | Not recorded | In 1 condition |
| MVKmevalonate kinase | Not recorded | In 1 condition |
| NLRP1NLR family pyrin domain containing 1 | Not recorded | In 1 condition |
| PMVKphosphomevalonate kinase | Not recorded | In 1 condition |
| POMPproteasome maturation protein | Not recorded | In 1 condition |
| RHBDF2rhomboid 5 homolog 2 | Not recorded | In 1 condition |
| TRPM4transient receptor potential cation channel subfamily M member 4 | Not recorded | In 1 condition |
| TRPV3transient receptor potential cation channel subfamily V member 3 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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