Trait

Cervical spine instability

An abnormal lack of stability of the cervical spine.

HPO HP:0010646

Body system: Abnormality of the musculoskeletal system

Read the genes linked to Cervical spine instability, and the rest of your genome, with one test.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test

10 genes linked to Cervical spine instability

Changes in these genes cause rare conditions in which Cervical spine instability is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
POP1POP1 ribonuclease P/MRP subunit	Always	In 1 condition
SOX9SRY-box transcription factor 9	Always	In 1 condition
B3GALT6beta-1,3-galactosyltransferase 6	Often (30–79%)	In 2 conditions
COL2A1collagen type II alpha 1 chain	Often (30–79%)	In 1 condition
ARSLarylsulfatase L	Sometimes (5–29%)	In 1 condition
TGFBR1transforming growth factor beta receptor 1	Sometimes (5–29%)	In 1 condition
COMPcartilage oligomeric matrix protein	Rarely (1–4%)	In 1 condition
SMAD3SMAD family member 3	Rarely (1–4%)	In 1 condition
TGFB3transforming growth factor beta 3	Rarely (1–4%)	In 1 condition
BGNbiglycan	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal cervical spine

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

One test. A lifetime of answers.