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Gene

SSR4

signal sequence receptor subunit 4

Summary

Cytogenetic location
Xq28
Coordinates
Chromosome X: 153,794,668–153,798,499 (GRCh38)
Exons
6 exons across 3.8 kb
Protein
173 amino acids
Also known as
TRAPD
MANE Select transcript
ENST00000370086.8NM_006280.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Congenital Disorders of Glycosylation

      • Congenital Disorders of Glycosylation (CDG)

        One of 98 genes linked to it

        A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

        • 2 GenCC submitters rate it definitive or strong

    How SSR4 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    Chromosome X, with a bracket where SSR4 sits. SSR4 and 34 genes near it on chromosome X, from 153,296,584 to 154,296,583.Chromosome XXq28p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28153.4 Mb153.6 Mb153.8 Mb154 Mb154.2 MbPNMA6F: 153,317,680–153,321,774, reverse strandPNMA6FZNF275: 153,334,122–153,360,110, forward strandZNF275PNMA6E: 153,395,639–153,401,392, reverse strandPNMA6EZFP92: 153,411,434–153,426,481, forward strandZFP92TREX2: 153,444,473–153,470,592, reverse strandTREX2HAUS7: 153,447,655–153,495,529, reverse strandHAUS7BGN: 153,488,654–153,510,711, forward strandBGNATP2B3: 153,517,620–153,582,939, forward strandATP2B3CCNQ: 153,587,925–153,600,045, reverse strandCCNQDUSP9: 153,642,397–153,651,326, forward strandDUSP9PNCK: 153,669,730–153,689,033, reverse strandPNCKSLC6A8: 153,687,914–153,696,591, forward strandSLC6A8BCAP31: 153,698,006–153,725,957, reverse strandBCAP31ABCD1: 153,724,495–153,744,755, forward strandABCD1PLXNB3: 153,764,179–153,779,346, forward strandSRPK3: 153,781,001–153,785,768, forward strandSRPK3IDH3G: 153,785,735–153,794,535, reverse strandIDH3GSSR4: 153,794,668–153,798,499, forward strandSSR4PDZD4: 153,802,161–153,830,935, reverse strandPDZD4L1CAM: 153,861,511–153,886,204, reverse strandL1CAM: 153,872,221–153,909,223, reverse strandAVPR2: 153,902,531–153,907,169, forward strandAVPR2ARHGAP4: 153,907,367–153,934,999, reverse strandARHGAP4NAA10: 153,928,799–153,935,083, reverse strandNAA10RENBP: 153,935,269–153,944,688, reverse strandHCFC1: 153,946,434–153,972,427, reverse strandHCFC1TMEM187: 153,972,290–153,983,194, forward strandIRAK1: 154,010,501–154,020,650, reverse strandIRAK1MECP2: 154,021,573–154,137,103, reverse strandMECP2OPN1LW: 154,144,243–154,159,032, forward strandOPN1LWOPN1MW: 154,182,596–154,196,861, forward strandOPN1MWOPN1MW2: 154,219,756–154,233,286, forward strandOPN1MW2OPN1MW3: 154,257,582–154,271,090, forward strandOPN1MW3TEX28: 154,271,265–154,295,853, reverse strandTEX28TKTL1: 154,295,795–154,330,350, forward strandTKTL1Diagram of SSR4: 6 exons on the forward strand of chromosome XExon 2: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 1: 153,794,668–153,794,754, 87 basesExon 2: 153,796,434–153,796,552, 119 basesExon 3: 153,797,458–153,797,532, 75 basesExon 4: 153,797,725–153,797,814, 90 basesExon 5: 153,798,071–153,798,136, 66 basesExon 6: 153,798,329–153,798,499, 171 bases1234565′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 0.6 kb of the gene's 3.8 kb; 522 of those bases code for the protein.

    How a genome test reads SSR4

    7

    positions in SSR4 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 3.8 kb of SSR4, introns included, not only the 0.6 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). SSR4 gene: signal sequence receptor subunit 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/ssr4

    Vancouver

    Dante Labs. SSR4 gene: signal sequence receptor subunit 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ssr4

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