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Gene

ARL6IP1

ARL6 interacting reticulophagy regulator 1

Summary

Cytogenetic location
16p12.3
Coordinates
Chromosome 16: 18,791,669–18,801,549 (GRCh38)
Exons
6 exons across 9.9 kb
Protein
203 amino acids
Also known as
AIP1, ARMER, KIAA0069, SPG61
Previous symbols
ARL6IP
MANE Select transcript
ENST00000304414.12NM_015161.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Hereditary Spastic Paraplegia

      • Hereditary Spastic Paraplegia (All Types)

        One of 66 genes linked to it

        Umbrella term covering all hereditary spastic paraplegias, including SPG4 (SPAST), the most common dominant form, and SPG5A, SPG6, SPG10, SPG18, SPG30 and SPG31.

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong

    How ARL6IP1 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 16, with a bracket where ARL6IP1 sits. ARL6IP1 and 11 genes near it on chromosome 16, from 18,296,609 to 19,296,608.Chromosome 1616p12.3p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.318.4 Mb18.6 Mb18.8 Mb19 Mb19.2 MbNPIPA8: 18,317,919–18,336,736, reverse strandNPIPA8NPIPA9: 18,358,086–18,379,331, reverse strandNPIPA9NOMO2: 18,417,325–18,562,211, reverse strandNOMO2RPS15A: 18,775,365–18,790,420, reverse strandRPS15A: 18,788,063–18,801,519, reverse strandARL6IP1: 18,791,669–18,801,549, reverse strandARL6IP1SMG1: 18,804,860–18,926,459, reverse strandSMG1TMC7: 18,983,928–19,063,947, forward strandTMC7COQ7: 19,067,564–19,082,190, forward strandCOQ7ITPRIPL2: 19,113,932–19,121,629, forward strandITPRIPL2SYT17: 19,167,971–19,268,334, forward strandSYT17CLEC19A: 19,285,731–19,322,145, forward strandCLEC19ADiagram of ARL6IP1: 6 exons on the reverse strand of chromosome 16Exon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 6: 18,791,669–18,793,370, 1,702 basesExon 5: 18,794,599–18,794,683, 85 basesExon 4: 18,795,464–18,795,581, 118 basesExon 3: 18,797,925–18,798,044, 120 basesExon 2: 18,798,701–18,798,834, 134 basesExon 1: 18,801,431–18,801,549, 119 bases6543215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.3 kb of the gene's 9.9 kb; 612 of those bases code for the protein.

    How a genome test reads ARL6IP1

    5

    positions in ARL6IP1 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 9.9 kb of ARL6IP1, introns included, not only the 2.3 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). ARL6IP1 gene: ARL6 interacting reticulophagy regulator 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/arl6ip1

    Vancouver

    Dante Labs. ARL6IP1 gene: ARL6 interacting reticulophagy regulator 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/arl6ip1

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