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Gene

UNC45B

unc-45 myosin chaperone B

Summary

Cytogenetic location
17q12
Coordinates
Chromosome 17: 35,147,817–35,189,343 (GRCh38)
Exons
20 exons across 41.5 kb
Protein
929 amino acids
Also known as
UNC45
Previous symbols
CMYA4
MANE Select transcript
ENST00000394570.7NM_001267052.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hereditary Congenital & Juvenile Cataract

    • Early-Onset Non-Syndromic Cataract

      Cataract that appears at birth or early in life without other features, caused by changes in lens genes such as the crystallins (CRYAA, CRYBB2, CRYGD and others), GJA3, GJA8 and MIP.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Early detection and surgery in children help prevent permanent vision loss from amblyopia, and family members can be offered eye checks.

  • Myofibrillar Myopathies

    • Myofibrillar myopathy

      A group of muscle disorders in which the contractile structure of muscle fibers breaks down, caused by genes such as DES, CRYAB, MYOT, LDB3, FLNC and BAG3.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Because the heart is often involved, regular heart checks (such as ECG and echocardiography) are recommended even without symptoms.

How UNC45B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where UNC45B sits. UNC45B and 17 genes near it on chromosome 17, from 34,668,580 to 35,668,579.Chromosome 1717q12p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.334.8 Mb35 Mb35.2 Mb35.4 Mb35.6 MbCCT6B: 34,927,842–34,981,078, reverse strandCCT6BZNF830: 34,961,540–34,963,777, forward strandZNF830LIG3: 34,980,462–35,009,743, forward strandLIG3RFFL: 35,005,990–35,089,899, reverse strandRFFL: 35,011,349–35,121,493, reverse strandRAD51D: 35,092,221–35,121,522, reverse strandRAD51DFNDC8: 35,121,615–35,130,732, forward strandFNDC8NLE1: 35,125,556–35,142,313, reverse strandNLE1UNC45B: 35,147,817–35,189,343, forward strandUNC45BSLC35G3: 35,192,520–35,194,393, reverse strandSLC35G3SLFN5: 35,243,043–35,273,655, forward strandSLFN5SLFN11: 35,350,305–35,373,701, reverse strandSLFN11SLFN12: 35,409,339–35,433,475, reverse strandSLFN12SLFN13: 35,435,096–35,449,766, reverse strandSLFN13SLFN12L: 35,464,249–35,537,770, reverse strandSLFN12LSLFN14: 35,543,985–35,560,819, reverse strandSLFN14PEX12: 35,574,795–35,578,863, reverse strandPEX12AP2B1: 35,578,046–35,726,417, forward strandAP2B1Diagram of UNC45B: 20 exons on the forward strand of chromosome 17Exon 17: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 1: 35,147,817–35,147,910, 94 basesExon 2: 35,148,264–35,148,431, 168 basesExon 3: 35,148,973–35,149,009, 37 basesExon 4: 35,150,048–35,150,223, 176 basesExon 5: 35,152,893–35,152,982, 90 basesExon 6: 35,154,574–35,154,741, 168 basesExon 7: 35,155,296–35,155,464, 169 basesExon 8: 35,159,375–35,159,545, 171 basesExon 9: 35,163,995–35,164,166, 172 basesExon 10: 35,168,061–35,168,361, 301 basesExon 11: 35,169,837–35,169,931, 95 basesExon 12: 35,170,114–35,170,255, 142 basesExon 13: 35,171,322–35,171,462, 141 basesExon 14: 35,174,242–35,174,369, 128 basesExon 15: 35,175,968–35,176,034, 67 basesExon 16: 35,177,017–35,177,130, 114 basesExon 17: 35,177,495–35,177,610, 116 basesExon 18: 35,180,559–35,180,676, 118 basesExon 19: 35,183,427–35,183,582, 156 basesExon 20: 35,186,299–35,189,343, 3,045 bases151015205′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.7 kb of the gene's 41.5 kb; 2,790 of those bases code for the protein.

How a genome test reads UNC45B

3

positions in UNC45B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 41.5 kb of UNC45B, introns included, not only the 5.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). UNC45B gene: unc-45 myosin chaperone B. Retrieved 17 October 2026, from https://dantelabs.com/genes/unc45b

Vancouver

Dante Labs. UNC45B gene: unc-45 myosin chaperone B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/unc45b

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