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Gene

CA12

carbonic anhydrase 12

Summary

Cytogenetic location
15q22.2
Coordinates
Chromosome 15: 63,321,378–63,381,846 (GRCh38)
Exons
11 exons across 60.5 kb
Protein
354 amino acids
Also known as
HsT18816
MANE Select transcript
ENST00000178638.8NM_001218.5
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads CA12 yet. The test sequences your whole genome, so your data includes it all the same.

How CA12 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where CA12 sits. CA12 and 8 genes near it on chromosome 15, from 62,851,612 to 63,851,611.Chromosome 1515q22.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.363 Mb63.2 Mb63.4 Mb63.6 Mb63.8 MbTPM1: 63,042,130–63,071,915, forward strandTPM1LACTB: 63,121,814–63,142,061, forward strandLACTBRPS27L: 63,125,859–63,158,021, reverse strandRPS27LRAB8B: 63,189,530–63,268,167, forward strandRAB8BAPH1B: 63,276,018–63,309,126, forward strandAPH1BCA12: 63,321,378–63,381,846, reverse strandCA12USP3: 63,504,501–63,594,640, forward strandUSP3FBXL22: 63,597,199–63,609,030, forward strandFBXL22HERC1: 63,608,618–63,833,997, reverse strandHERC1Diagram of CA12: 11 exons on the reverse strand of chromosome 15Exon 10: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 11: 63,321,378–63,326,357, 4,980 basesExon 10: 63,327,149–63,327,233, 85 basesExon 9: 63,328,098–63,328,130, 33 basesExon 8: 63,338,819–63,338,945, 127 basesExon 7: 63,340,288–63,340,445, 158 basesExon 6: 63,340,720–63,340,783, 64 basesExon 5: 63,342,002–63,342,097, 96 basesExon 4: 63,345,477–63,345,619, 143 basesExon 3: 63,346,530–63,346,709, 180 basesExon 2: 63,375,658–63,375,678, 21 basesExon 1: 63,381,636–63,381,846, 211 bases1110864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.1 kb of the gene's 60.5 kb; 1,065 of those bases code for the protein.

Sequencing CA12

6

positions in CA12 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 60.5 kb of CA12, introns included, not only the 6.1 kb of exons.

Traits linked to CA12

The Human Phenotype Ontology lists these as features of the rare conditions CA12 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CA12 gene: carbonic anhydrase 12. Retrieved 17 October 2026, from https://dantelabs.com/genes/ca12

Vancouver

Dante Labs. CA12 gene: carbonic anhydrase 12 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ca12

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