Gene
GNAS-AS1
GNAS antisense RNA 1
- HGNC 24872↗(opens in a new tab)
- Ensembl gene ENSG00000235590↗(opens in a new tab)
- NCBI Gene 149775↗(opens in a new tab)
Summary
- Cytogenetic location
- 20q13.32
- Coordinates
- Chromosome 20: 58,818,918–58,850,902 (GRCh38)
- Exons
- 5 exons across 32 kb
- Also known as
- SANG, NESP-AS, NESPAS, GNAS1AS, NCRNA00075
- Previous symbols
- GNASAS, GNAS-AS
- MANE Select transcript
- ENST00000718285.1NR_185847.1
- Locus type
- Long non-coding RNA (lncRNA)
This page as data
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How GNAS-AS1 is laid out
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 1 kb of the gene's 32 kb.
Sequencing GNAS-AS1
6Easy
How hard GNAS-AS1 is to sequence with short reads, out of 100
0 · Easy100 · Hard
Almost all of GNAS-AS1's exons sit where short reads map cleanly.
What adds to it: the share of GNAS-AS1's exons in each kind of hard region
- MappabilityStretches where 100 or 250 bp reads cannot be placed uniquely, so a call there may be missing or wrong. Weight 100%.0%
- HomologySegmental duplications: copies elsewhere in the genome, such as paralogues and pseudogenes, at 90% identity or more. Weight 60%.0%
- Shared with chrYThe pseudoautosomal regions and the X-transposed region, where chrX and chrY carry the same or nearly the same sequence, so reads from either may land on the other. Weight 60%.0%
- Reference coverageGaps in the reference assembly nearby, where there is no sequence for reads to align to. Weight 50%.0%
- RepeatsTandem repeats and runs of one base, which reads slip on and may not span. Weight 30%.3.3%
- GC contentWindows under 25% or over 65% G and C, which library preparation covers thinly. Weight 20%.24%
A Dante Labs score from our own research, built on NIST's Genome in a Bottle maps of hard-to-sequence regions.How it's scoredEach bar is the share of GNAS-AS1's exon bases in that kind of difficult region. Any one kind can make a gene hard on its own, and each further kind adds less: 0 when no base is in any, 100 when every base is where reads cannot be placed uniquely.
Traits linked to GNAS-AS1
The Human Phenotype Ontology lists these as features of the rare conditions GNAS-AS1 can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). GNAS-AS1 gene: GNAS antisense RNA 1. Retrieved 19 October 2026, from https://dantelabs.com/genes/gnas-as1
Dante Labs. GNAS-AS1 gene: GNAS antisense RNA 1 [Internet]. [cited 19 October 2026]. Available from: https://dantelabs.com/genes/gnas-as1
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