Gene
TRPM6
transient receptor potential cation channel subfamily M member 6
- HGNC 17995(opens in a new tab)
- Ensembl gene ENSG00000119121(opens in a new tab)
- NCBI Gene 140803(opens in a new tab)
Summary
- Cytogenetic location
- 9q21.13
- Coordinates
- Chromosome 9: 74,722,495–74,887,921 (GRCh38)
- Exons
- 39 exons across 165.4 kb
- Protein
- 2,022 amino acids
- Also known as
- CHAK2, FLJ22628
- Previous symbols
- HOMG, HSH
- MANE Select transcript
- ENST00000360774.6NM_017662.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Familial Hypomagnesemia
- Familial Primary Hypomagnesemia
A group of inherited magnesium-wasting disorders caused by variants in genes such as CLDN16, CLDN19, TRPM6, CNNM2 and FXYD2; the CLDN16 and CLDN19 forms can progress to chronic kidney disease.
- 3 GenCC submitters rate it definitive or strong
What knowing changes
Magnesium supplementation can control symptoms, and some forms need kidney function and eye monitoring.
How TRPM6 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 8.3 kb of the gene's 165.4 kb; 6,069 of those bases code for the protein.
How a genome test reads TRPM6
46
positions in TRPM6 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 165.4 kb of TRPM6, introns included, not only the 8.3 kb of exons.
Traits linked to TRPM6
The Human Phenotype Ontology lists these as features of the rare conditions TRPM6 can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). TRPM6 gene: transient receptor potential cation channel subfamily M member 6. Retrieved 17 October 2026, from https://dantelabs.com/genes/trpm6
Dante Labs. TRPM6 gene: transient receptor potential cation channel subfamily M member 6 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/trpm6
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