Betegségjelentés · Immunological

Hyper-IgM Syndrome

Inherited conditions in which the immune system cannot switch from making IgM antibodies to IgG, IgA and IgE, so IgM is normal or high while other antibodies are low. The X-linked form (CD40LG) also weakens T-cell help and raises the risk of opportunistic infections and liver disease; other forms involve CD40, AICDA and UNG.

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