Trait
Increased connective tissue
The presence of an abnormally increased amount of connective tissue.
Summary
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
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Get my Genome Test18 genes linked to Increased connective tissue
Changes in these genes cause rare conditions in which Increased connective tissue is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACTA1actin alpha 1, skeletal muscle | Always | In 2 conditions |
| PSKH1protein serine kinase H1 | Always | In 1 condition |
| LAMA2laminin subunit alpha 2 | Very often (80–99%) | In 1 condition |
| AIFM1apoptosis inducing factor mitochondria associated 1 | Often (30–79%) | In 1 condition |
| KLHL40kelch like family member 40 | Often (30–79%) | In 1 condition |
| KLHL41kelch like family member 41 | Often (30–79%) | In 1 condition |
| LMOD3leiomodin 3 | Often (30–79%) | In 1 condition |
| NEBnebulin | Often (30–79%) | In 1 condition |
| RYR1ryanodine receptor 1 | Often (30–79%) | In 2 conditions |
| GATA1GATA binding protein 1 | Sometimes (5–29%) | In 1 condition |
| NEFLneurofilament light chain | Sometimes (5–29%) | In 1 condition |
| TNXBtenascin XB | Sometimes (5–29%) | In 1 condition |
| UROSuroporphyrinogen III synthase | Sometimes (5–29%) | In 1 condition |
| ANO5anoctamin 5 | Not recorded | In 1 condition |
| DYSFdysferlin | Not recorded | In 1 condition |
| LIMS2LIM zinc finger domain containing 2 | Not recorded | In 1 condition |
| PLECplectin | Not recorded | In 1 condition |
| TCAPtitin-cap | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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