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Trait

Decreased memory B cell proportion

A reduction in the normal proportion of memory B cells (CD19+/CD27+) in circulation relative to the total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV).

HPO HP:0030374

Summary

Body system
Abnormality of blood and blood-forming tissuesAbnormality of the immune system

10 condition reports read genes linked to this trait

Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.

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13 genes linked to Decreased memory B cell proportion

Changes in these genes cause rare conditions in which Decreased memory B cell proportion is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ARHGEF1Rho guanine nucleotide exchange factor 1AlwaysIn 1 condition
BACH2BACH transcriptional regulator 2AlwaysIn 1 condition
CTPS1CTP synthase 1AlwaysIn 1 condition
ELF4E74 like ETS transcription factor 4AlwaysIn 1 condition
IKBKBinhibitor of nuclear factor kappa B kinase subunit betaAlwaysIn 1 condition
IRF4interferon regulatory factor 4AlwaysIn 1 condition
POMPproteasome maturation proteinAlwaysIn 1 condition
PRKCDprotein kinase C deltaAlwaysIn 1 condition
KDM6Alysine demethylase 6AVery often (80–99%)In 1 condition
KMT2Dlysine methyltransferase 2DVery often (80–99%)In 1 condition
IL27RAinterleukin 27 receptor subunit alphaOften (30–79%)In 1 condition
SP110SP110 nuclear body proteinOften (30–79%)In 1 condition
TOM1target of myb1 membrane trafficking proteinNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

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Abnormal memory B cell proportion

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.19-9814e911.

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