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Gene

DLC1

DLC1 Rho GTPase activating protein

Summary

Cytogenetic location
8p22
Coordinates
Chromosome 8: 13,083,361–13,514,851 (GRCh38)
Exons
18 exons across 431.5 kb
Protein
1,528 amino acids
Also known as
HP, ARHGAP7, STARD12, DLC-1, p122-RhoGAP
MANE Select transcript
ENST00000276297.9NM_182643.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Nephrotic Syndrome

    • Nephrosis

      Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.

      • 1 GenCC submitter rates it definitive or strong

How DLC1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 8, with a bracket where DLC1 sits. DLC1 and 3 genes near it on chromosome 8, from 12,651,870 to 13,946,342.Chromosome 88p22p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.312.8 Mb13 Mb13.2 Mb13.4 Mb13.6 Mb13.8 MbLONRF1: 12,721,897–12,756,073, reverse strandLONRF1TRMT9B: 12,945,642–13,031,503, forward strandTRMT9BDLC1: 13,083,361–13,514,851, reverse strandDLC1C8orf48: 13,566,869–13,568,288, forward strandC8orf48Diagram of DLC1: 18 exons on the reverse strand of chromosome 8Exon 18: 13,083,361–13,085,931, 2,571 basesExon 17: 13,086,290–13,086,463, 174 basesExon 16: 13,088,487–13,088,704, 218 basesExon 15: 13,090,252–13,090,470, 219 basesExon 14: 13,091,318–13,091,432, 115 basesExon 13: 13,092,612–13,092,825, 214 basesExon 12: 13,094,759–13,094,957, 199 basesExon 11: 13,095,086–13,095,245, 160 basesExon 10: 13,098,399–13,098,575, 177 basesExon 9: 13,099,347–13,100,770, 1,424 basesExon 8: 13,102,790–13,102,853, 64 basesExon 7: 13,110,742–13,110,823, 82 basesExon 6: 13,115,586–13,115,657, 72 basesExon 5: 13,305,269–13,305,302, 34 basesExon 4: 13,393,553–13,393,693, 141 basesExon 3: 13,401,470–13,401,619, 150 basesExon 2: 13,499,049–13,500,196, 1,148 basesExon 1: 13,514,602–13,514,851, 250 bases181015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.4 kb of the gene's 431.5 kb; 4,587 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DLC1 gene: DLC1 Rho GTPase activating protein. Retrieved 17 October 2026, from https://dantelabs.com/genes/dlc1

Vancouver

Dante Labs. DLC1 gene: DLC1 Rho GTPase activating protein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dlc1

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