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Gene

ITSN2

intersectin 2

Summary

Cytogenetic location
2p23.3
Coordinates
Chromosome 2: 24,202,864–24,360,536 (GRCh38)
Exons
40 exons across 157.7 kb
Protein
1,697 amino acids
Also known as
KIAA1256, SWAP, SH3P18, SWA, PRO2015
Previous symbols
SH3D1B
MANE Select transcript
ENST00000355123.9NM_006277.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Nephrotic Syndrome

    • Nephrosis

      Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.

      • 1 GenCC submitter rates it definitive or strong

How ITSN2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 2, with a bracket where ITSN2 sits. ITSN2 and 12 genes near it on chromosome 2, from 23,781,700 to 24,781,699.Chromosome 22p23.3p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.323.8 Mb24 Mb24.2 Mb24.4 Mb24.6 MbATAD2B: 23,748,664–23,927,221, reverse strandATAD2BUBXN2A: 23,926,788–24,004,909, forward strandUBXN2AMFSD2B: 24,009,826–24,063,679, forward strandWDCP: 24,029,347–24,049,575, reverse strandWDCPFKBP1B: 24,049,674–24,067,714, forward strandFKBP1BSF3B6: 24,066,654–24,076,476, reverse strandSF3B6FAM228B: 24,076,526–24,169,642, forward strandFAM228BTP53I3: 24,077,433–24,085,861, reverse strandTP53I3PFN4: 24,112,083–24,123,734, reverse strandPFN4: 24,124,366–24,190,436, forward strandFAM228A: 24,175,051–24,200,849, forward strandFAM228AITSN2: 24,202,864–24,360,536, reverse strandITSN2NCOA1: 24,490,983–24,770,702, forward strandNCOA1Diagram of ITSN2: 40 exons on the reverse strand of chromosome 2Exon 40: 24,202,864–24,203,783, 920 basesExon 39: 24,204,245–24,204,418, 174 basesExon 38: 24,205,214–24,205,297, 84 basesExon 37: 24,208,237–24,208,319, 83 basesExon 36: 24,209,100–24,209,221, 122 basesExon 35: 24,209,818–24,210,033, 216 basesExon 34: 24,210,780–24,210,947, 168 basesExon 33: 24,212,650–24,212,748, 99 basesExon 32: 24,216,049–24,216,232, 184 basesExon 31: 24,217,907–24,218,013, 107 basesExon 30: 24,220,945–24,221,066, 122 basesExon 29: 24,246,129–24,246,320, 192 basesExon 28: 24,246,797–24,246,893, 97 basesExon 27: 24,248,629–24,248,750, 122 basesExon 26: 24,248,837–24,248,882, 46 basesExon 25: 24,252,345–24,252,511, 167 basesExon 24: 24,254,367–24,254,431, 65 basesExon 23: 24,257,888–24,258,093, 206 basesExon 22: 24,261,106–24,261,250, 145 basesExon 21: 24,261,561–24,261,742, 182 basesExon 20: 24,270,671–24,270,768, 98 basesExon 19: 24,271,766–24,271,941, 176 basesExon 18: 24,275,713–24,275,849, 137 basesExon 17: 24,284,763–24,284,843, 81 basesExon 16: 24,286,212–24,286,351, 140 basesExon 15: 24,293,688–24,293,775, 88 basesExon 14: 24,295,664–24,295,804, 141 basesExon 13: 24,298,665–24,298,814, 150 basesExon 12: 24,299,909–24,300,171, 263 basesExon 11: 24,301,154–24,301,239, 86 basesExon 10: 24,301,965–24,302,102, 138 basesExon 9: 24,303,799–24,303,862, 64 basesExon 8: 24,308,617–24,308,756, 140 basesExon 7: 24,310,284–24,310,380, 97 basesExon 6: 24,310,489–24,310,692, 204 basesExon 5: 24,312,212–24,312,375, 164 basesExon 4: 24,313,460–24,313,523, 64 basesExon 3: 24,315,132–24,315,224, 93 basesExon 2: 24,328,052–24,328,115, 64 basesExon 1: 24,360,304–24,360,536, 233 bases40353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.1 kb of the gene's 157.7 kb; 5,094 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ITSN2 gene: intersectin 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/itsn2

Vancouver

Dante Labs. ITSN2 gene: intersectin 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/itsn2

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