Trait
Butterfly vertebrae
A butterfly vertebra (sagittal cleft vertebra or anterior rachischisis) is a sagittal defect in the vertebral body caused by failure of fusion of the two lateral chondrification centers during embryogenesis. The name is based on the appearance of the two hemivertebrae emerging as butterfly wings from the central cleft on x-ray.
Summary
- Also called
- Anterior rachischisis, Sagittal clefting of vertebrae
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test22 genes linked to Butterfly vertebrae
Changes in these genes cause rare conditions in which Butterfly vertebrae is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DMRT2doublesex and mab-3 related transcription factor 2 | Always | In 1 condition |
| KDM6Alysine demethylase 6A | Always | In 2 conditions |
| KMT2Dlysine methyltransferase 2D | Always | In 2 conditions |
| NKX3-2NK3 homeobox 2 | Always | In 1 condition |
| SC5Dsterol-C5-desaturase | Always | In 1 condition |
| COG1component of oligomeric golgi complex 1 | Often (30–79%) | In 2 conditions |
| CSGALNACT1chondroitin sulfate N-acetylgalactosaminyltransferase 1 | Often (30–79%) | In 1 condition |
| HAAO3-hydroxyanthranilate 3,4-dioxygenase | Often (30–79%) | In 1 condition |
| LAMA5laminin subunit alpha 5 | Often (30–79%) | In 1 condition |
| OTUD5OTU deubiquitinase 5 | Often (30–79%) | In 1 condition |
| RIPPLY2ripply transcriptional repressor 2 | Often (30–79%) | In 1 condition |
| WBP11WW domain binding protein 11 | Often (30–79%) | In 1 condition |
| ARSLarylsulfatase L | Sometimes (5–29%) | In 1 condition |
| FOXF1forkhead box F1 | Sometimes (5–29%) | In 1 condition |
| IPO8importin 8 | Sometimes (5–29%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Sometimes (5–29%) | In 1 condition |
| SOX5SRY-box transcription factor 5 | Sometimes (5–29%) | In 1 condition |
| STAG2STAG2 cohesin complex component | Sometimes (5–29%) | In 1 condition |
| TBX6T-box transcription factor 6 | Sometimes (5–29%) | In 1 condition |
| ALG12ALG12 alpha-1,6-mannosyltransferase | Not recorded | In 1 condition |
| SIX6SIX homeobox 6 | Not recorded | In 1 condition |
| SOX2SRY-box transcription factor 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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