Traits

Traits linked to DVL3

dishevelled segment polarity protein 3

The Human Phenotype Ontology links 105 traits to DVL3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Cleft tongue	Always
Gum enlargement	Always
Midface retrusion	Always
Nasal tip, upturned	Always
Short nose	Always
Wide nasal bridge	Always
Wide nose	Very often (80–99%)
Abnormality of the gums	Often (30–79%)
Absence of adult teeth	Often (30–79%)
Big calvaria	Often (30–79%)
Broad opening between the eyelids	Often (30–79%)
Central cleft palate	Often (30–79%)
Cleft palate	Often (30–79%)
Corners of eye widely separated	Often (30–79%)
Curly eyelashes	Often (30–79%)
Depressed nasal bridge	Often (30–79%)
Downturned corners of mouth	Often (30–79%)
Euryblepharon	Often (30–79%)
Eye folds	Often (30–79%)
Frontal bossing	Often (30–79%)
High, narrow palate	Often (30–79%)
Little lower jaw	Often (30–79%)
Long eyelashes	Often (30–79%)
Long philtrum	Often (30–79%)
Open bite	Often (30–79%)
Prominent forehead	Often (30–79%)
Receding chin	Often (30–79%)
Upward slanting of the opening between the eyelids	Often (30–79%)
Bad bite	Sometimes (5–29%)
Cleft lip	Sometimes (5–29%)
Downward slanting of the opening between the eyelids	Sometimes (5–29%)
Extra teeth	Sometimes (5–29%)
Failure of development of all teeth	Sometimes (5–29%)
Failure of development of between one and six teeth	Sometimes (5–29%)
Failure of development of more than six teeth	Sometimes (5–29%)
High forehead	Sometimes (5–29%)
Short neck	Sometimes (5–29%)
Short philtrum	Sometimes (5–29%)
Triangular mouth	Sometimes (5–29%)
Webbed neck	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Curvature of digit	Always
Disproportionately short middle portion of limb	Always
Short fingers or toes	Always
Short palm	Very often (80–99%)
Smaller or shorter than typical limbs	Very often (80–99%)
Curvature of little finger	Often (30–79%)
Short finger bones	Often (30–79%)
Avascular necrosis of the capital femoral epiphysis	Sometimes (5–29%)
Broad thumb	Sometimes (5–29%)
Coxa valga	Sometimes (5–29%)
Coxa vara	Sometimes (5–29%)
Elbow dislocation	Sometimes (5–29%)
Finger syndactyly	Sometimes (5–29%)
Hip dislocation	Sometimes (5–29%)
Permanent flexion of the finger	Sometimes (5–29%)
Webbed fingers or toes	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Short penis	Always
Undescended testes	Always
Underdeveloped penis	Very often (80–99%)
Small clitoris	Often (30–79%)
Small labia majora	Often (30–79%)
Underdeveloped inner lips	Often (30–79%)
Abnormality of the penis	Sometimes (5–29%)
Epispadias	Sometimes (5–29%)
Hypospadias	Sometimes (5–29%)
Vesicoureteral reflux	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Abnormal vertebral body morphology	Often (30–79%)
Funnel chest	Often (30–79%)
Hunched back	Often (30–79%)
Missing part of vertebrae	Often (30–79%)
Scoliosis	Often (30–79%)
Abnormal formation of the hip	Sometimes (5–29%)
Permanent flexion of the finger or toe	Sometimes (5–29%)
Pigeon chest	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Hole in heart wall separating two lower heart chambers	Often (30–79%)
Patent ductus arteriosus	Sometimes (5–29%)
Patent foramen ovale	Sometimes (5–29%)
Pulmonary artery atresia	Sometimes (5–29%)
Strawberry birthmark	Sometimes (5–29%)
Tricuspid regurgitation	Sometimes (5–29%)
Underdeveloped right heart	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Abnormal fingernail development	Sometimes (5–29%)
Hair loss	Sometimes (5–29%)
Overgrowth and curving of fingernail	Sometimes (5–29%)
Port-wine stain on eyelid	Sometimes (5–29%)
Ridged fingernail	Sometimes (5–29%)
Spinal dimple	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Umbilical hernia	Often (30–79%)
Anteriorly placed anus	Sometimes (5–29%)
Femoral hernia	Sometimes (5–29%)
Inguinal hernia	Sometimes (5–29%)
Omphalocele	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Wide-set eyes	Very often (80–99%)
Blue outer white part of eyeball	Often (30–79%)
Bulging eye	Often (30–79%)
Cross-eyed	Sometimes (5–29%)
Drooping upper eyelid	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Ears rotated toward back of head	Sometimes (5–29%)
Hearing impairment	Sometimes (5–29%)
Low-set ears	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Sometimes (5–29%)
Intellectual disability	Sometimes (5–29%)
Specific learning disability	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Short stature	Always
Severe short stature	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DVL3 and how often each is seen. Find out more at hpo.jax.org.

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