Trait

Femoral hernia

A hernia which occurs just below the inguinal ligament, where abdominal contents pass through a naturally occurring weakness called the femoral canal.

HPO HP:0100541

Also called: Crural hernia
Body system: Abnormality of the digestive system Abnormality of the musculoskeletal system

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18 genes linked to Femoral hernia

Changes in these genes cause rare conditions in which Femoral hernia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
EFEMP1EGF-like fibulin extracellular matrix protein 1	Always	In 1 condition
PTDSS1phosphatidylserine synthase 1	Often (30–79%)	In 1 condition
SLC26A2solute carrier family 26 member 2	Often (30–79%)	In 1 condition
SLC2A10solute carrier family 2 member 10	Often (30–79%)	In 1 condition
TRIP11thyroid hormone receptor interactor 11	Often (30–79%)	In 1 condition
ATP7AATPase copper transporting alpha	Sometimes (5–29%)	In 1 condition
CAMSAP1calmodulin regulated spectrin associated protein 1	Sometimes (5–29%)	In 1 condition
COL1A1collagen type I alpha 1 chain	Sometimes (5–29%)	In 1 condition
COL1A2collagen type I alpha 2 chain	Sometimes (5–29%)	In 1 condition
DIS3L2DIS3 like 3'-5' exoribonuclease 2	Sometimes (5–29%)	In 1 condition
DVL1dishevelled segment polarity protein 1	Sometimes (5–29%)	In 1 condition
DVL3dishevelled segment polarity protein 3	Sometimes (5–29%)	In 1 condition
EHMT1euchromatic histone lysine methyltransferase 1	Sometimes (5–29%)	In 1 condition
FANCBFA complementation group B	Sometimes (5–29%)	In 1 condition
FZD2frizzled class receptor 2	Sometimes (5–29%)	In 1 condition
SMAD4SMAD family member 4	Sometimes (5–29%)	In 1 condition
WNT5AWnt family member 5A	Sometimes (5–29%)	In 1 condition
TBX1T-box transcription factor 1	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Hernia of the abdominal wall

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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