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Gene

CADM3

cell adhesion molecule 3

Summary

Cytogenetic location
1q23.2
Coordinates
Chromosome 1: 159,171,615–159,203,313 (GRCh38)
Exons
9 exons across 31.7 kb
Protein
398 amino acids
Also known as
BIgR, FLJ10698, TSLL1, NECL1, SynCAM3, Necl-1
Previous symbols
IGSF4B
MANE Select transcript
ENST00000368125.9NM_001127173.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Charcot-Marie-Tooth Disease

      • One of 62 genes linked to it

        A group of inherited peripheral neuropathies causing progressive weakness and wasting of the distal muscles and loss of sensation, mainly in the feet and hands.

        • ClinGen rates the link moderate
        • 1 GenCC submitter rates it definitive or strong
        What knowing changes

        Genetic counseling, subtype-specific monitoring, physical therapy, orthotics, neurotoxic drug avoidance, gene-specific clinical trials, surveillance for associated features

    How CADM3 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    Chromosome 1, with a bracket where CADM3 sits. CADM3 and 17 genes near it on chromosome 1, from 158,687,464 to 159,687,463.Chromosome 11q23.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44158.8 Mb159 Mb159.2 Mb159.4 Mb159.6 MbOR6K2: 158,699,678–158,700,652, reverse strandOR6K2OR6K3: 158,716,327–158,720,720, reverse strandOR6K3OR6N1: 158,747,814–158,772,195, reverse strandOR6N1OR6K6: 158,754,720–158,755,891, forward strandOR6K6OR6N2: 158,774,222–158,781,204, reverse strandOR6N2MNDA: 158,802,264–158,849,517, forward strandMNDAPYHIN1: 158,930,779–158,977,059, forward strandPYHIN1IFI16: 158,999,938–159,055,156, forward strandIFI16PYDC5: 158,999,971–159,002,751, reverse strandPYDC5AIM2: 159,056,129–159,188,222, reverse strandAIM2CADM3: 159,171,615–159,203,313, forward strandCADM3ACKR1: 159,204,568–159,206,500, forward strandACKR1FCER1A: 159,289,714–159,308,224, forward strandFCER1AOR10J3: 159,313,720–159,314,659, reverse strandOR10J3OR10J4: 159,432,204–159,433,138, forward strandOR10J4OR10J1: 159,437,845–159,443,078, forward strandOR10J1OR10J5: 159,535,078–159,536,007, reverse strandOR10J5APCS: 159,587,818–159,602,430, forward strandAPCSDiagram of CADM3: 9 exons on the forward strand of chromosome 1Exon 4: 1 known disease-causing siteExon 1: 159,171,615–159,171,853, 239 basesExon 2: 159,191,936–159,192,076, 141 basesExon 3: 159,192,578–159,192,730, 153 basesExon 4: 159,193,423–159,193,560, 138 basesExon 5: 159,193,870–159,194,040, 171 basesExon 6: 159,196,364–159,196,454, 91 basesExon 7: 159,196,891–159,197,060, 170 basesExon 8: 159,199,751–159,199,876, 126 basesExon 9: 159,200,804–159,203,313, 2,510 bases1246895′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3.7 kb of the gene's 31.7 kb; 1,197 of those bases code for the protein.

    How a genome test reads CADM3

    1

    position in CADM3 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 31.7 kb of CADM3, introns included, not only the 3.7 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). CADM3 gene: cell adhesion molecule 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/cadm3

    Vancouver

    Dante Labs. CADM3 gene: cell adhesion molecule 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cadm3

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