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Gene

DRP2

dystrophin related protein 2

Summary

Cytogenetic location
Xq22.1
Coordinates
Chromosome X: 101,219,786–101,264,502 (GRCh38)
Exons
24 exons across 44.7 kb
Protein
957 amino acids
MANE Select transcript
ENST00000395209.8NM_001939.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Charcot-Marie-Tooth Disease

      • One of 62 genes linked to it

        A group of inherited peripheral neuropathies causing progressive weakness and wasting of the distal muscles and loss of sensation, mainly in the feet and hands.

        • 1 GenCC submitter rates it definitive or strong
        What knowing changes

        Genetic counseling, subtype-specific monitoring, physical therapy, orthotics, neurotoxic drug avoidance, gene-specific clinical trials, surveillance for associated features

    How DRP2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome X, with a bracket where DRP2 sits. DRP2 and 19 genes near it on chromosome X, from 100,742,144 to 101,742,143.Chromosome XXq22.1p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28100.8 Mb101 Mb101.2 Mb101.4 Mb101.6 MbCSTF2: 100,820,331–100,843,533, forward strandCSTF2NOX1: 100,843,324–100,874,464, reverse strandNOX1XKRX: 100,886,924–100,929,433, reverse strandXKRXARL13A: 100,969,708–100,990,831, forward strandARL13ATRMT2B: 100,973,670–101,052,135, reverse strandTRMT2BTMEM35A: 101,078,870–101,096,367, forward strandTMEM35ACENPI: 101,098,150–101,166,126, forward strandCENPIDRP2: 101,219,786–101,264,502, forward strandDRP2TAF7L: 101,268,253–101,293,057, reverse strandTAF7LTIMM8A: 101,320,050–101,349,001, reverse strandTIMM8ABTK: 101,349,338–101,390,796, reverse strandBTKRPL36A: 101,390,824–101,396,155, forward strandRPL36ARPL36A-HNRNPH2: 101,391,011–101,412,297, forward strandRPL36A-HNRNPH2GLA: 101,393,273–101,408,012, reverse strandGLAHNRNPH2: 101,408,114–101,414,778, forward strandARMCX4: 101,418,269–101,535,551, forward strandARMCX1: 101,550,411–101,554,704, forward strandARMCX1ARMCX6: 101,615,118–101,618,011, reverse strandARMCX6ARMCX3: 101,622,797–101,627,843, forward strandARMCX3ARMCX2: 101,654,024–101,659,924, reverse strandARMCX2Diagram of DRP2: 24 exons on the forward strand of chromosome XExon 7: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 1: 101,219,786–101,220,146, 361 basesExon 2: 101,224,604–101,224,706, 103 basesExon 3: 101,231,585–101,231,764, 180 basesExon 4: 101,235,860–101,236,023, 164 basesExon 5: 101,237,619–101,237,775, 157 basesExon 6: 101,238,981–101,239,101, 121 basesExon 7: 101,241,668–101,241,936, 269 basesExon 8: 101,242,325–101,242,471, 147 basesExon 9: 101,242,904–101,242,982, 79 basesExon 10: 101,245,017–101,245,077, 61 basesExon 11: 101,245,388–101,245,449, 62 basesExon 12: 101,247,090–101,247,164, 75 basesExon 13: 101,248,089–101,248,290, 202 basesExon 14: 101,248,514–101,248,599, 86 basesExon 15: 101,250,423–101,250,580, 158 basesExon 16: 101,250,917–101,251,083, 167 basesExon 17: 101,252,605–101,252,716, 112 basesExon 18: 101,254,425–101,254,561, 137 basesExon 19: 101,254,859–101,254,924, 66 basesExon 20: 101,255,184–101,255,249, 66 basesExon 21: 101,256,118–101,256,261, 144 basesExon 22: 101,258,309–101,258,546, 238 basesExon 23: 101,260,049–101,260,169, 121 basesExon 24: 101,260,497–101,264,502, 4,006 bases15101520245′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 7.3 kb of the gene's 44.7 kb; 2,874 of those bases code for the protein.

    How a genome test reads DRP2

    3

    positions in DRP2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 44.7 kb of DRP2, introns included, not only the 7.3 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). DRP2 gene: dystrophin related protein 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/drp2

    Vancouver

    Dante Labs. DRP2 gene: dystrophin related protein 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/drp2

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