Traits

Traits linked to COMP

cartilage oligomeric matrix protein

The Human Phenotype Ontology links 91 traits to COMP, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of limbs

Trait	How often it is seen
Dropped arches	Always
Short fingers or toes	Always
Irregular wide portion of a long bone	Very often (80–99%)
Outward bow-leggedness	Very often (80–99%)
Thenar muscle atrophy	Very often (80–99%)
Broad wide portion of long bone	Often (30–79%)
Increased laxity of fingers	Often (30–79%)
Knee joint over-flexibility	Often (30–79%)
Limb undergrowth	Often (30–79%)
Limited elbow extension	Often (30–79%)
Short finger bones	Often (30–79%)
Shortening of all metacarpals	Often (30–79%)
Wind-swept deformity of the knees	Often (30–79%)
Abnormal maturation of thigh bone head and neck	Sometimes (5–29%)
Abnormality of the hipbone socket	Sometimes (5–29%)
Abnormality of thighbone end part	Sometimes (5–29%)
Acetabular dysplasia	Sometimes (5–29%)
Ankle hypermobility	Sometimes (5–29%)
Flared wide portion of long bone	Sometimes (5–29%)
Flat acetabular roof	Sometimes (5–29%)
Increased mobility in finger joint	Sometimes (5–29%)
Irregular acetabular roof	Sometimes (5–29%)
Irregular wrist bones	Sometimes (5–29%)
Knock knees	Sometimes (5–29%)
Short neck of thighbone	Sometimes (5–29%)
Small innermost thighbone end part	Sometimes (5–29%)
Avascular necrosis of the capital femoral epiphysis	Rarely (1–4%)
Coxa vara	Rarely (1–4%)
Back knee	Not recorded
Broad femoral neck	Not recorded
Flared femoral metaphysis	Not recorded
Radial metaphyseal irregularity	Not recorded
Short outermost finger bone	Not recorded
Shortened long bone of hand	Not recorded
Small carpal bones	Not recorded
Small end part of finger bones	Not recorded
Ulnar deviation of the hand	Not recorded
Ulnar deviation of the wrist	Not recorded
Ulnar metaphyseal irregularity	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Abnormal development of end part of bone	Always
Ankle pain	Always
Delayed maturation of end part of long bone	Always
Irregular end part of long bone	Always
Limited hip movement	Always
Scoliosis	Always
Beaking of vertebral bodies	Very often (80–99%)
Double-Jointed	Very often (80–99%)
Flattened vertebrae	Very often (80–99%)
Hand pain	Very often (80–99%)
Abnormal formation of the hip	Often (30–79%)
Abnormal vertebral body morphology	Often (30–79%)
Degenerative joint disease	Often (30–79%)
Distal joint hypermobility	Often (30–79%)
Excessive inward curvature of lower spine	Often (30–79%)
Hip joint pain	Often (30–79%)
Hypermobility of all joints	Often (30–79%)
Knee pain	Often (30–79%)
Limited shoulder movement	Often (30–79%)
Short long bone	Often (30–79%)
Cone-shaped end part of bone	Sometimes (5–29%)
Hypoplastic pelvis	Sometimes (5–29%)
Joint stiffness	Sometimes (5–29%)
Limitation of joint mobility	Sometimes (5–29%)
Limited hip extension	Sometimes (5–29%)
Skeletal myopathy	Sometimes (5–29%)
Small end part of bone	Sometimes (5–29%)
Cervical spine instability	Rarely (1–4%)
Hypoplasia of the odontoid process	Rarely (1–4%)
Atlantoaxial dislocation	Not recorded
Fragmented end part of bone	Not recorded
Fragmented, irregular end part of bone	Not recorded
Hip osteoarthritis	Not recorded
Hunched back	Not recorded
Irregular vertebral endplates	Not recorded
Ovoid vertebral bodies	Not recorded
Spatulate ribs	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Constrictive median neuropathy	Always
Hand tingling	Always
Positive Phalen test	Always
Positive carpal Tinel sign	Very often (80–99%)
Abnormal gait	Often (30–79%)
Waddling gait	Often (30–79%)
Cervical cord compression	Not recorded
Damage to nerves that sense feeling	Not recorded

Growth abnormality

Trait	How often it is seen
Mild short stature	Always
Disproportionate short-limb short stature	Very often (80–99%)
Disproportionate short stature	Sometimes (5–29%)
Childhood onset short-limb short stature	Not recorded
Severe short stature	Not recorded

Constitutional symptom

Trait	How often it is seen
Joint pain	Often (30–79%)
Postexertional symptom exacerbation	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to COMP and how often each is seen. Find out more at hpo.jax.org.

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