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Gene

F10

coagulation factor X

Summary

Cytogenetic location
13q34
Coordinates
Chromosome 13: 113,122,799–113,149,529 (GRCh38)
Exons
8 exons across 26.7 kb
Protein
488 amino acids
Inheritance
Autosomal recessive
Also known as
fX
MANE Select transcript
ENST00000375559.8NM_000504.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Rare Inherited Coagulation Factor Deficiencies

    • Congenital Vitamin K-Dependent Coagulation Factor DeficienciesAutosomal recessive

      Inherited deficiencies of prothrombin (factor II), factor VII or factor X, or of all vitamin K-dependent factors together (caused by changes in GGCX or VKORC1), which can cause nosebleeds, easy bruising and bleeding after injury, surgery or childbirth.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing in advance allows factor replacement to be planned around surgery and childbirth; the combined form often responds to vitamin K.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How F10 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 13, with a bracket where F10 sits. F10 and 12 genes near it on chromosome 13, from 112,636,164 to 113,636,163.Chromosome 1313q34p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34112.8 Mb113 Mb113.2 Mb113.4 Mb113.6 MbATP11A: 112,689,911–112,887,177, forward strandATP11AMCF2L: 112,894,330–113,100,412, forward strandMCF2LF7: 113,105,762–113,120,685, forward strandF7F10: 113,122,799–113,149,529, forward strandF10PROZ: 113,158,388–113,173,625, forward strandPROZPCID2: 113,177,117–113,209,458, reverse strandPCID2CUL4A: 113,208,193–113,267,108, forward strandCUL4ALAMP1: 113,297,088–113,324,413, forward strandLAMP1GRTP1: 113,320,007–113,364,165, reverse strandGRTP1ADPRHL1: 113,399,611–113,453,914, reverse strandADPRHL1DCUN1D2: 113,455,289–113,490,984, reverse strandDCUN1D2SLC9D1: 113,490,719–113,554,590, forward strandSLC9D1TFDP1: 113,584,525–113,641,509, forward strandTFDP1Diagram of F10: 8 exons on the forward strand of chromosome 13Exon 2: 7 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 5: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 8: 11 known disease-causing sitesExon 1: 113,122,799–113,122,925, 127 basesExon 2: 113,129,452–113,129,612, 161 basesExon 3: 113,138,457–113,138,481, 25 basesExon 4: 113,139,357–113,139,470, 114 basesExon 5: 113,140,919–113,141,050, 132 basesExon 6: 113,143,851–113,144,095, 245 basesExon 7: 113,147,379–113,147,496, 118 basesExon 8: 113,148,916–113,149,529, 614 bases123456785′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.5 kb of the gene's 26.7 kb; 1,467 of those bases code for the protein.

How a genome test reads F10

29

positions in F10 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 26.7 kb of F10, introns included, not only the 1.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). F10 gene: coagulation factor X. Retrieved 16 October 2026, from https://dantelabs.com/genes/f10

Vancouver

Dante Labs. F10 gene: coagulation factor X [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/f10

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