Skip to content
Use your HSA or FSA funds

Gene

TPM4

tropomyosin 4

Summary

Cytogenetic location
19p13.12-p13.11
Coordinates
Chromosome 19: 16,076,495–16,103,002 (GRCh38)
Exons
8 exons across 26.5 kb
Protein
248 amino acids
MANE Select transcript
ENST00000643579.2NM_003290.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TPM4 yet. The test sequences your whole genome, so your data includes it all the same.

How TPM4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where TPM4 sits. TPM4 and 24 genes near it on chromosome 19, from 15,589,749 to 16,589,748.Chromosome 1919p13.12-p13.11p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4315.6 Mb15.8 Mb16 Mb16.2 Mb16.4 MbCYP4F8: 15,615,218–15,630,639, forward strandCYP4F8CYP4F3: 15,640,795–15,662,825, forward strandCYP4F3CYP4F12: 15,673,018–15,698,819, forward strandCYP4F12OR10H2: 15,728,024–15,729,052, forward strandOR10H2OR10H3: 15,737,985–15,742,343, forward strandOR10H3OR10H5: 15,787,661–15,800,357, forward strandOR10H5OR10H1: 15,804,549–15,815,664, reverse strandOR10H1CYP4F2: 15,877,893–15,900,528, reverse strandCYP4F2CYP4F11: 15,912,367–15,934,933, reverse strandCYP4F11OR10H4: 15,944,299–15,950,350, forward strandOR10H4TPM4: 16,076,495–16,103,002, forward strandTPM4RAB8A: 16,111,653–16,134,235, forward strandRAB8AHSH2D: 16,134,028–16,158,575, forward strandHSH2DCIB3: 16,161,368–16,173,525, reverse strandCIB3FAM32A: 16,185,378–16,192,048, forward strandFAM32AAP1M1: 16,197,854–16,245,906, forward strandAP1M1KLF2: 16,324,613–16,328,685, forward strandKLF2EPS15L1: 16,354,591–16,472,085, reverse strandEPS15L1CALR3: 16,479,061–16,496,167, reverse strandCALR3: 16,479,067–16,628,204, reverse strandC19orf44: 16,496,385–16,521,369, forward strandC19orf44CHERP: 16,517,882–16,542,547, reverse strandCHERPSLC35E1: 16,549,831–16,572,432, reverse strandSLC35E1MED26: 16,574,907–16,629,062, reverse strandMED26: 16,577,642–16,660,115, reverse strandDiagram of TPM4: 8 exons on the forward strand of chromosome 19Exon 4: 1 known disease-causing siteExon 1: 16,076,495–16,076,697, 203 basesExon 2: 16,081,913–16,082,046, 134 basesExon 3: 16,086,423–16,086,540, 118 basesExon 4: 16,088,027–16,088,097, 71 basesExon 5: 16,089,045–16,089,120, 76 basesExon 6: 16,093,536–16,093,598, 63 basesExon 7: 16,093,684–16,093,753, 70 basesExon 8: 16,101,264–16,103,002, 1,739 bases124685′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 26.5 kb; 747 of those bases code for the protein.

How a genome test reads TPM4

1

position in TPM4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 26.5 kb of TPM4, introns included, not only the 2.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TPM4 gene: tropomyosin 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/tpm4

Vancouver

Dante Labs. TPM4 gene: tropomyosin 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tpm4

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test